Science - USA (2021-11-12)

SCIENCEscience.org 12 NOVEMBER 2021¥VOL 374 ISSUE 6569 873 Fig. 5. Stimulation of LBD T cells witha-synuclein promotesIL-17A exp ...

that promoted expression ofIL17A, a pro- inflammatory cytokine involved in autoimmune diseases ( 21 ). In animal models of neuro ...

and remains in one cell in regions 2b to 3, where it forms distinct foci in the cytoplasm (Fig. 2, A and A′). This cell will bec ...

distributed more homogeneously (Fig. 3, B and C, and movies S3 and S4). Patronin is therefore required for MTOC formation in the ...

does not accumulate in one cell and fails to form foci (Fig. 4C). Furthermore, loss of Shot prevents Patronin from associating w ...

domain of Patronin, but not the CKK domain ( 25 ), also prevents Patronin accumulation in the pro-oocyte (fig. S6, C and D). Thu ...

this creates a positive feedback loop: As Dynein transports more Patronin and MTs into the cell with the most stabilized MT minu ...

200 Swedish kronor (SEK; about US$24) con- ditional on getting vaccinated. The Swedish setting allows us to link individual-leve ...

control condition. Immediately after the treat- ment, we measured participants’intentions to get vaccinated against COVID-19. Ex ...

did behavioral nudges. Although the preregis- tered main analysis focused on the comparison between each of the experimental con ...

TRANSCRIPTION Structural basis of Integrator-mediated transcription regulation Isaac Fianu^1 , Ying Chen^1 , Christian Dienemann ...

contact the SPT5 domain KOWx-4, which forms a clamp on exiting RNA (Fig. 2B and figs. S4H, S5C, and S6D). The active center groo ...

subunit INTS3 ( 31 , 32 ), which is also mobile but located nearby according to our cross- linking data (figs. S5A and S6E). Clo ...

that Integrator binding is inconsistent with EC formation (fig. S8). Integrator excludes PAF binding because the N-terminal regi ...

data collection, processing, and structural modeling. O.D., A.L., and H.U. performed mass spectrometric analysis. P.C. designed ...

in heat-producing elements, but these basalts appear to be compositionally fractionated, so the presence of these evolved minera ...

that mobilized Pb would also cause excess scatter in the isochron (i.e., specific minerals offset from the isochron by more than ...

The emplacement age of 1963 ± 57 Ma that we infer for the Em4 unit provides a calibra- tion point for the lunar crater size-freq ...

MINERALOGY Discovery of davemaoite, CaSiO 3 -perovskite, as a mineral from the lower mantle Oliver Tschauner^1 *, Shichun Huang^ ...

tetragonal structure ( 17 ) and mapped the tetragonal Brillouin zone onto that of the cubic structure. Intensities are based on ...