Science - USA (2021-12-03)

groups ( 21 ). As expected from B4GALT1’s role in processing N-linked carbohydrate, all samples had normal profiles for ApoCIII ...

decrease in body weight; 0.001 <P< 0.04 and 0.004 <P< 0.03 for heterozygotes and homozygotes, respectively; analysis ...

O. Staretz-Chachamet al.,Clin. Genet. 97 , 920– 926 (2020). C. Pérez-Cerdáet al.,J. Pediatr. 183 , 170–177.e1 (2017). O. Iourin ...

1228 3 DECEMBER 2021¥VOL 374 ISSUE 6572 science.orgSCIENCE Fig. 1. Cells deficient in O 2 reduction retain the capacity to input ...

input of electrons into the ETC, we monitored the activity of DHODH. DHODH oxidizes di- hydroorotate into orotate and deposits t ...

1230 3 DECEMBER 2021¥VOL 374 ISSUE 6572 science.orgSCIENCE Fig. 2. Upon inhibition of O 2 reduction, fumarate accepts electrons ...

SCIENCEscience.org 3 DECEMBER 2021¥VOL 374 ISSUE 6572 1231 Fig. 3. Fumarate reduction is required to maintain nucleotide biosynt ...

tracing of^13 C 515 N 2 -glutamine requires a ratio- metric analysis of labeled succinate to labeled fumarate to normalize for d ...

SCIENCEscience.org 3 DECEMBER 2021¥VOL 374 ISSUE 6572 1233 Fig. 4. Fumarate reduction supports mitochondrial functions in tissue ...

had a higher rate of succinate oxidation than fumarate reduction, whereas the opposite was the case in antimycin-treated mitocho ...

in theDYMito, which was restored to pretreat- ment levels with a similar timing as it takes for antimycin to increase fumarate r ...

driven by an increase in fumarate reduction, we calculated the ratio of the absolute con- centration of^13 C 3 -succinate to tha ...

K. K. Brown, J. B. Spinelli, J. M. Asara, A. Toker,Cancer Discov. 7 , 391–399 (2017). J. Rohlena, L.-F. Dong, S. J. Ralph, J. N ...

topological nature of the state by measur- ing the topological entanglement entropy. By simulating interferometry of toric code ...

allowed us to compute the second Rényi entro- py. We used an iterative Bayesian scheme ( 32 ) to mitigate measurement errors and ...

bosonic exchange statistics, their combination yexhibits fermionic exchange statistics. The mutual and exchange statistics of th ...

gate errors, suggesting that continued efforts are needed to decrease the cycle duration and improve coherence. Discussion Our s ...

TOPOLOGICAL MATTER Probing topological spin liquids on a programmable quantum simulator G. Semeghini^1 , H. Levine^1 , A. Keesli ...

(Fig. 1E), indicating an approximate dimer covering. Measuring topological string operators A defining property of a phase with ...

hiZ ¼ðÞ 1 #enclosed vertices(Fig.2B).Thepres- ence of monomers or double-dimers reduces the effective contribution of each verte ...