Science - USA (2021-12-10)

are committed to the neuronal lineage ( 16 ). We used a list of established markers to delineate both types of progenitor cells ...

Shiet al.,Science 374 , eabj6641 (2021) 10 December 2021 4 of 12 RGC IPC Pseudotime 0 5 GW9 12 13 16 18 pL3 pM4 pM3 pM1 pM2 pL2 ...

Shiet al.,Science 374 , eabj6641 (2021) 10 December 2021 5 of 12 A B D Branch point 1 MGE LGE/CGE C towards MGE towards LGE/CGE ...

Shiet al.,Science 374 , eabj6641 (2021) 10 December 2021 6 of 12 D2 MSN D1 MSN (TSHZ1) Striatal projection neuron precursors OB ...

binding 2), andPAX6, were enriched among L3 cells (Fig. 4A and fig. S6, A and B). We combined LGE progenitors and post- mitotic ...

Shiet al.,Science 374 , eabj6641 (2021) 10 December 2021 8 of 12 A F G B MGE M1 M2 M3 M4 M5 M6 M7 C PV+ basket cells PV+ chandel ...

the embryonic SST+ transcriptional identities (MGESST4, 8, 9, and 11) share similarities with both the Martinotti cell and non-M ...

interneurons in the adult cortex of mice and humans. For instance,LHX6+LAMP5+ inter- neurons are much more abundant in the human ...

variation and cell types in neurodevelop- mental disorders. Materials and methods summary Detailed materials and methods are pro ...

R. Tremblay, S. Lee, B. Rudy, GABAergic interneurons in the neocortex: From cellular properties to circuits.Neuron 91 , 260 – 2 ...

RESEARCH ARTICLES ◥ CORONAVIRUS Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccineÐboosted nonhuman primates Kizzme ...

respectively, after ~6 months (week 29). Boost- ing with mRNA-1273 or mRNA-1273.binduced fourfold and about sixfold increases in ...

than at week 6 for both boost groups; e.g., week 31d-specific neutralizing antibody re- sponses were fivefold greater than week ...

(fig. S3F). Together, these data show mRNA- 1273.bgiven as a primary regimen elicits high- erb-specific responses compared with ...

imprints homologous or heterologous boost, we performed temporal analysis of WA-1 andb S-specific memory B cells (fig. S7). Afte ...

not TH2 responses, were induced at week 6, 2 weeks after mRNA-1273 vaccination (Fig. 5). In these NHPs, TH1 and TFHresponses wer ...

SCIENCEscience.org 10 DECEMBER 2021¥VOL 374 ISSUE 6573 1349 B C DE F G A TCID 50 /Swab Fig. 6. Efficacy of mRNA-1273 against upp ...

with symptomatic disease or increased fre- quency of severe disease when infected with thedvariant ( 33 ). Likeb,dalso includes ...

durable and broader immunity and could reduce morbidity and mortality until greater population immunity is achieved. Materials a ...

bind to saturation. Graphs represent reference- subtracted relative“analyte binding late”report points (RUs), determined by alig ...