Science - USA (2021-12-17)
using default Giraffe and VG-MAP. For com- parison,wemappedthesamereadstoGRCh38 with BWA-MEM. Genotyping accuracy We compared th ...
M. Fagnyet al., Exploring regulation in tissues with eQTL networks.Proc. Natl. Acad. Sci. U.S.A. 114 , E7841–E7850 (2017). doi: ...
Publishyourresearch intheSciencefamilyofjournals TheSciencefamilyofjournals(Science, Science Advances,ScienceImmunology, Science ...
RESEARCH ARTICLE SUMMARY ◥ CANCER IMMUNOLOGY Pan-cancer single cell landscape of tumor-infiltrating T cells Liangtao Zheng†, Shi ...
RESEARCH ARTICLE ◥ CANCER IMMUNOLOGY Pan-cancer single-cell landscape of tumor-infiltrating T cells Liangtao Zheng^1 †, Shishang ...
Zhenget al.,Science 374 , eabe6474 (2021) 17 December 2021 2 of 11 Fig. 1. Pan-cancer T cell profile at the single-cell resoluti ...
indicating that this metacluster contained both MAIT and non-MAIT Tc17 cells (desig- nated Tc17 hereafter). ThecompositionsofTce ...
Zhenget al.,Science 374 , eabe6474 (2021) 17 December 2021 4 of 11 Fig. 2. Heterogeneity and dynamics of CD8+exhausted T cells.( ...
T cells (figs. S18). Because of the scarcity of these two cell populations, it remains to be seen whetherTCF7+Texcells were deri ...
generalized additive model) (Fig. 3B). Also, the TFRUNX3(runt-related transcription factor 3) exhibited elevated expression at a ...
target genes, most of which were also signa- ture genes ofTNFRSF9+Tregcells, including TNFRSF4,TNFRSF9,ID3(inhibitor of DNA bind ...
the head and neck squamous cell carcinoma showing the highest median value (2.63%), a subset of melanoma samples could reach a f ...
frequencies. This association might be medi- ated by theFAT1-Hippo-YAP1 (yes-associated protein 1) pathway dysfunction in cancer ...
from single-cell suspensions. The libraries of single-cell transcriptome and single-cell TCR were prepared by means of a 10x Chr ...
ACKNOWLEDGMENTS We thank Y. Yang, B. Zhang, Y. Gao, Y. Li, M. Gao, K. Wang, D. Lin, L. Zhou, and L. Jiang for clinical sample co ...
GOLDOPENACCESS,DIGITAL,ANDFREETO ALLREADERS AsAAAS’s firstmultidisciplinary, openaccessjournal,ScienceAdvancespublishes research ...
RESEARCH ARTICLE SUMMARY ◥ CORONAVIRUS Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated w ...
RESEARCH ARTICLE ◥ CORONAVIRUS Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the ...
sample of infections, we can exclude, with 95% confidence, a population prevalence of non- Delta lineages greater than 0.004%, c ...
to doubling times of 11 days (CrI 7, 23 days) and 25 days (15, >50 days) respectively. Across rounds 12 and 13,Rwas 1.28 (CrI ...
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