Textbook of Personalized Medicine - Second Edition [2015]

446 Personalized Management of Pain Interindividual differences in the experience of pain have been appreciated clini- cally for ...

447 The molecular mechanisms that underlie pain vary among individuals over time and among different types of pain to produce wi ...

448 Genetic Mutations with Loss of Pain Complete prevention of pain has so far been seen in 6 distinct rare hereditary syn- drom ...

449 intervals in clinical trials can convey clinically meaningful information regarding the impact of a pain treatment on health ...

450 and the effi cacy for morphine in cancer pain treatment. Genetic variation in the COMT gene can infl uence the effi cacy of ...

451 that alter splice variant expression could predispose patients to differences in disease progression. Genetically defi ned v ...

452 Personalized Analgesics Pharmacogenetics has been used in drug development and clinical pharmacology of various diseases but ...

453 Clinical diagnosis of type of pain & cause Acute inflammatory pain Resonse to common analgesics Chronic Yes pain Testing ...

454 Personalized Management of Traumatic Brain Injury Molecular Basis of Management of Traumatic Brain Injury There is considera ...

455 patient centered personalized care. The fi nding that higher REM density in depressed patients is associated with better res ...

456 SPTBN2, SACS, MRE11, KCNC3 and DARS2 of which nine were novel including one causing a newly described recessive ataxia syndr ...

457 Blair DR, Lyttle CS, Mortensen JM, et al. A nondegenerate code of deleterious variants in Mendelian loci contributes to comp ...

458 Habek M, Borovecki F, Brinar VV. Genomics in multiple sclerosis. Clin Neurol Neurosurg. 2010;112:621–4. He ZW, Qu J, Zhang Y ...

459 Martinez-Forero I, Pelaez A, Villoslada P. Pharmacogenomics of multiple sclerosis: in search for a personalized therapy. Exp ...

460 Tfelt-Hansen P. Triptans versus other migraine medicine–secondary publication. Ugeskr Laeger. 2009;171:1485–7. Tfelt-Hansen ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_13, 461 © Springer Science+Business Media New York 2 ...

462 Although the basic biology of some of the genes involved in psychiatric disorders is now known, it is still not clear how sp ...

463 transporter may have a reduced ability to move serotonin. Therefore, this person may be less likely to respond to antidepres ...

464 negative responses in others, perhaps related to individual variations in monaminer- gic function and monoamine system genes ...

465 Personalized Antipsychotic Therapy Although considerable advances have taken place in the pharmacotherapy of schizophrenia, ...