Textbook of Personalized Medicine - Second Edition [2015]

466 Many antipsychotics, including perphenazine, zuclopenthixol, thioridazine, hal- operidol and risperidone, are metabolized to ...

467 variation that correlates with drug effi cacy. Safer and more effective medicines should arise when this information is inco ...

468 for the therapeutic effects of antidepressants, a new antidepressant pharmacother- apy could be developed to activate that s ...

469 show a relationship between brain function changes during brief placebo treatment and later side effects during treatment wi ...

470 react adversely. This necessitates a review of the initial treatment choice, often involving extended periods of illness whi ...

471 Usually genetic profi les cannot predict a large percentage of variation in response to citalopram. Data available through t ...

472 tracked their response to a course of antidepressant drugs. They found three com- mon variations in the human version of sFR ...

473 Genotype and Response to Methylphenidate in Children with ADHD Methylphenidate acts primarily by inhibiting the dopamine tra ...

474 Since 2007, the National Institute of Drug Abuse (NIDA) has sought SNPs for inclusion in a custom microarray platform to stu ...

475 personalized treatment option. New treatment strategies focusing on genes contribut- ing to drug and alcohol dependence (suc ...

476 With advances in molecular biology and genomics technology, individualization of smoking cessation therapy according to geno ...

477 References Alemi F, Zargoush M, Erdman H, et al. Genetic markers anticipate response to citalopram in a majority of patients ...

478 Sjoqvist F, Eliasson E. The convergence of conventional therapeutic drug monitoring and pharma- cogenetic testing in persona ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_14, 479 © Springer Science+Business Media New York 2 ...

480 It is estimated that ~12,000 genes are expressed in the cardiovascular system assuming that the total number of genes in the ...

481 Table 14.1 Gene polymorphisms relevant to cardiovascular disease management Gene polymorphism Effect Signifi cance for manag ...

482 Role of Diagnostics in Personalized Management of Cardiovascular Disease Cardiovascular Disorders with a Genetic Component S ...

Table 14.2 Genes that cause cardiovascular diseases Category Disease Gene Function Congenital malformations Atrial septal defect ...

484 effect on phenotype. Protein-coding regions of genes in participants of European or African ancestry in the Exome Sequencing ...

485 Instead of focusing on so-called candidate genes with known functions that are highly suspect in heart beat rhythm, the rese ...