Textbook of Personalized Medicine - Second Edition [2015]

486 NGS Sequencing for Management of Cardiovascular Disorders Current PCR-based strategies are inadequate for genomic investigat ...

487 artery disease. A genotype score of nine validated SNPs that are associated with modulation in levels of LDL or HDL choleste ...

488 content of all lipids, components, and subclasses. VAP is an expanded cholesterol profi le that provides direct, detailed me ...

489 Modifying the Genetic Risk for Myocardial Infarction Variants in the 5-lipoxygenase–activating protein (FLAP) gene are assoc ...

490 and intracoronary imaging) mean that there will a need for some guidelines in selection of the procedure best suited for an ...

491 nervous system and that patients with the D allele may thus derive greater benefi ts from pharmacologic interventions to dec ...

492 research on the effi cacy of therapies for heart failure in black patients. This analysis, combined with other recent data f ...

493 warrant treatment and helps to establish the absolute benefi ts that patients can expect from particular treatments. The ben ...

494 Choice of Drugs for Hypertension Over 100 medications are available for treatment of HPN in several categories: diuretics, α ...

495 blood pressure pathways that can lead to future development of drug target for hypertension and may guide therapy for clinic ...

496 Pharmacogenomics of Diuretic Drugs Diuretics are considered to be the fi rst-line drugs for HPN but their overall effi cacy ...

497 drug as fi rst line treatment leading to reduction of the number of drugs required for adequate treatment as well the number ...

498 stroke when treated with diuretics compared with other antihypertensive therapies. With regard to BP response, interactions ...

499 drug treatment, the magnitude of plasma lipid responses to drug therapies varies considerably among individuals modifi ed by ...

500 reductase gene may experience signifi cantly smaller reductions in cholesterol when treated with pravastatin. The absolute d ...

501 Prediction of Response to Statins Statins are the most frequently prescribed drugs for lowering LDL-cholesterol (LDLC) level ...

502 The protective effect of a key genetic variant may be overwhelmed by the use of hormone replacement therapy. The results of ...

503 This is a clinically signifi cant mutation, since it is relatively common (found in 3–6 % of Caucasian subjects) and has bee ...

504 Heparin-induced antibodies recognize and bind to heparin-platelet factor 4 complexes and subsequently activate platelets via ...

505 diphosphate (ADP) P2Y12 receptor on platelets for their lifespan, thereby inhibit- ing their activation and decreasing subse ...