Organic Chemistry of Drug Synthesis. Volume 7
reagent and formation of 180. The ester grouping is next reduced to the corre- sponding carbinol ( 181 ). Swern oxidation with o ...
antidepressantigemsine( 191 ) acts by some other as yet undefined mecha- mism. The compound is described as a ligand for sigma r ...
ether in the antagonist toremifene ( 196 )^32 is replaced by a simple hydroxyethyl group. This agent is prepared starting with a ...
200 O=HC OCH 2 C 6 H 5 + F H 2 N 201 OCH 2 C 6 H 5 F N 202 OCH 2 C 6 H 5 F N CH 3 O 2 C COCl CH 3 O 2 C 203 204 O Bu 3 N C=O CH ...
L.A. Sobrera, P.A. Leeson, J.A. Castaner, M. del Fresno,Drugs Future 29 , 240 (2002). K. Imaki, Y. Arai, T. Okegawa, U.S. Paten ...
CHAPTER 4 CARBOCYCLIC COMPOUNDS FUSED TO A BENZENE RING The nucleus of a modest number of new compounds comprise a two- or three ...
both reduce the double bond and to remove the benzyl protecting group ( 4 ). Reaction of 4 with hydrogen bromide then cleaves th ...
anticholinergic activity, and has been proposed for treatment of Alzheimer’s disease. Condensation of piperidine aldehyde ( 10 ) ...
The hormone melatonin ( 30 ) is intimately involved in the diurnal cycle with levels rising late in the day prior to sleep. Cong ...
bromide proceeds to the allyl ether ( 24 ). Heating compound 24 leads to a Claisen rearrangement to theC-allyl derivative ( 25 ) ...
includes a substituted naphthyl moiety, has shown preliminaryin vivo activity. The convergent synthesis starts with construction ...
dopamine itself is too hydrophilic to penetrate the brain from the circula- tion. A tetrahydronaphthalene derivative that incorp ...
The effects on cell proliferation of retinoids has led to the investigation of structurally related compounds as potential antin ...
60 CH 3 + ClOC CO 2 CH 3 57 AlCl 3 CH 3 O CO 2 CH 3 61 (C 6 H 5 )PCH 3 + CH 3 CO 2 H CH 3 CO 2 CH 3 NaOH 63 62 The saga of estro ...
O OCH 3 64 HCO 2 C 2 H5 NaOC 2 H5 O OCH 3 CHO- Na+ CH 3 O CH 2 P(C 6 H 5 ) 3 CH 3 O CH 2 Cl (C 6 H 5 ) 3 P 65 66 67 O OCH 3 CH 3 ...
4. OTHER BENZOFUSED CARBOCYCLIC COMPOUNDS Multidrug resistance, as noted earlier, is the all too prevalent phenomenon where a pa ...
The carbinol ( 82 ) is then converted to the halide with thionyl chloride apparently with retention of configuration ( 83 ). Dis ...
the phenol ( 98 ) is obtained by treatment of 97 with butyllithium and diph- enylphosphine. The product ( 98 ) is then alkylated ...
M. Chorev, T. Goren, Y. Herzig, J. Sterling, M. Weinstock-Rosin, M.B.H. Youdim, U.S. Patent 6,462,222 (2002). K. Chilma_Blair, ...
CHAPTER 5 5 FIVE-MEMBERED HETEROCYCLES The specific chapter to which a given drug is assigned is to some extent arbitrary. More ...
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