Organic Chemistry of Drug Synthesis. Volume 7
A rather more complex antifungal compound incorporates in its struc- ture both a triazole and a triazolone ring. The lengthy seq ...
group for the next reaction. This last intermediate ( 180 ) is reacted with the diaryl piperazine (181a) in the presence of base ...
nitrogen atom is then introduced by treating the enolate from 188 with tosyl azide. Catalytic hydrogenation then reduces the azi ...
The ring hydroxyl group is then acylated with the fluorinated benzoyl chlor- ide ( 194 ) to yield ester 195. Reaction with the c ...
process of infection. Synthesis of this agent starts by protection of the amino group in the bridged bicyclic amine ( 201 ). The ...
of a halomethyl carbonyl group with an amide. Thus, condensation of the cinnamic amide ( 219 ) with 1,3-dichloroacetone leads to ...
carbamate. The nitrile group is then transformed to a tetrazole by reaction with sodium azide in the presence of aluminum chlori ...
protecting group to reveal the free phenol ( 235 ). Reaction of 235 with hexamethylene tetramine (HMTA) in acid leads to formyla ...
with the benzylic halide on the tetrazole-substituted biphenyl ( 246 )to afford the alkylated product ( 247 ). Saponfication of ...
R.R. Bartlett, F.-J. Kammerer, U.S. Patent 5,949,511 (1996). P.T. Gallagher, T.A. Hicks, G.W. Mullier, U.S. Patent 4,892,963 (1 ...
...
CHAPTER 6 6 SIX-MEMBERED HETEROCYCLES 1. COMPOUNDS WITH ONE HETEROATOM A. Pyridines Agents that interact with cholinergic recept ...
N N CH 3 1 N N CH 3 2 I Cl PdPh 3 PCl CuI iPr3Si N N Cl CH^3 iPr 3 Si 3 N N Cl CH^3 iPr 3 Si ZnAcOH 4 N N Cl CH^3 5 Bu 4 N+ F- A ...
ketone ( 11 ). The central ring is formed by a newly devised pyridine syn- thesis. The first step involves reaction of chloroace ...
applications of this compound. The synthesis of this compound begins with addition of the Grignard reagent from substituted the ...
of the more important pitfalls in cancer chemotherapy. Considerable effort has been devoted to finding drugs, so-called chemosen ...
inhibitor antiviral drugtiprinavir( 52 ) notably departs from this pattern as it omits the peptide-like moiety present in the ea ...
Reaction of this intermediate with base leads the anion of the newly revealed hydroxyl group to attack with the carboxylate in w ...
In a classic sequence for building a pyrimidine ring, the aniline ( 57 )is condensed with cyanamide. Addition of the basic nitro ...
replaced by chlorine by reaction with phosphorus oxychloride. Treatment of product 64 with bromine replaces the remaining hydrog ...
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