Organic Chemistry of Drug Synthesis. Volume 7
O-alkyl product ( 35 ). Reaction of intermediate 35 with oxalyl chloride proceeds on the only open position of the heterocyclic ...
hydrolysis opens the ring to afford the intermediate mercapto aniline, the sequence in effect having delivered sulfur to the ort ...
that ring due the presence of both the ether and the amine functions. Construction of the second ring begins with the alkylation ...
the side chain starts with the condensation of dimethylglyoxylate ( 63 ) with guanidine to afford the pyrimidol ( 64 ). The hydr ...
substituent to the fused heterocyclic ring ( 77 ). The methyl group at the 2 position on this ring is next oxidized with NBS and ...
agents. Solid tumors are highly dependent on the growth of new blood vessels, a process termed neoangiogenisis, which provide ox ...
with methyl orthoformate in strong acid then introduces a formyl group at the only open position on the ring ( 92 ). Condensatio ...
oxirane to form the dioxin ring ( 102 ). Reaction of this last compound with carbon tetrabromide in the presence of triphenylpho ...
facilitate this reaction. The anion is of course not isolated, and is next quenched withN-fluorobenzenesulfonimide to afford 110 ...
isoindolone ( 117 ). A second hydrogenation step reduces the nitro group to an aniline to affordlenalidomide( 118 ).^16 D. Misce ...
polypeptide; the drug does so by stimulating secretion of growth hormone from the pituitary gland. This agent has shown promisin ...
bromine by the basic nitrogen on the eneamine; conjugate addition of the active methylene group to the quinone then closes the r ...
2. FIVE-MEMBERED RINGS WITH TWO HETEROCYCLIC ATOMS A. Benzimidazoles Thrombin is an essential intermediate in the formation of b ...
treated with thiazolidinedione proper ( 153 ) in the presence of base. The anion from the methylene group in 153 adds to the ald ...
the heterocyclic part of those molecules is replaced by benzene, though the example at hand includes a normal sugar. Thus, coupl ...
recent atypical drug is a mixed agonist–antagonist at dopamine receptors. The partial agonist activity should in theory avoid th ...
enantiomer of this compound is far more active than its antipode both in vitroandin vivo. One of several methods for preparing t ...
E. Comer, W.S. Murphy, ARKIVOC, 286 (2003). A.D. Palkowitz et al.,J. Med. Chem. 40 , 1407 (1997). N.H. Hauel, H. Nar, H. Priepe ...
...
CHAPTER 8 SIX-MEMBERED HETEROCYCLES FUSED TO ONE BENZENE RING 1. COMPOUNDS WITH ONE HETEROATOM A. Benzopyrans A prominent featur ...
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