Principles and Practice of Pharmaceutical Medicine

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24 Pharmacoepidemiology and the Pharmaceutical Physician Hugh H. Tilson The specialty practice of preventive medicine extends in ...

physicians need an understanding of the funda- mentals of this field, in order to understand and harness the value that epidemio ...

Case–control study designs Thesewere developed to provide information more rapidly than when cohorts are followed for pro- longe ...

and if so, then to suggest what its parameters might be. 24.4 The ‘wired’ epidemiologist It probably goes without saying in the ...

These are thus measures of incidence. The propor- tion of a population that will experience at least one seizure or one migraine ...

24.7 Epidemiology in drug registration and licensing During the registration process, there is typically repeated interaction be ...

challenging but vital during the early period after launch. The assessment of pharmacovigilance findings, particularly the initi ...

registered before their outcome is known: the diagnosed birth anomaly can cause bias in report- ing frequency, and converts a pr ...

degree as well as at least one year of structured training or ‘practicum’. Again, European equiva- lents exist. A four to five-y ...

International Society for Pharmacoepidemiology (ISPE). 2003.Data Privacy Protections (www. pharmacoepi. org). Last JM. 2001.Dict ...

25 Statistical Principles and Application in Biopharmaceutical Research Dan Anbar 25.1 The scientific method and the role of the ...

25.2 The statistical method: making decisions under conditions of uncertainty The scientific method runs into difficulties when ...

test variable is defined (‘The mean change in the pretreatment to posttreatment blood pressure’). (c) A statistical hypothesis i ...

probability that the statistical test would be signifi- cant if the effect of the drug is to reduce the diastolic blood pressure ...

Clearly, the larger the ‘signal-to-noise ratio’, the easier it is to establish a causal relationship. Thus, in a clinical drug t ...

the set of all possible posttreatment minus pretreat- ment blood pressure measurements) with standard deviation of 10.5 would ha ...

their response to treatment. These could be related to the subject demographic background, such as age, sex and ethnic origin, g ...

The most common source of bias is one resulting from subjects being selected to the different treat- ment groups in a way that c ...

Group B of those who do not. The results are presented in Table 25.4. We notice that the two groups of subjects have different m ...