Science - USA (2022-03-04)

RESEARCH ARTICLE ◥ NEUROGENOMICS A single-cell atlas of the normal and malformed human brain vasculature Ethan A. Winkler1,2,3,4 ...

Winkleret al.,Science 375 , eabi7377 (2022) 4 March 2022 2 of 12 A B Vascular Neurons/glia Immune Endothelial Pericyte Smooth mu ...

markers and relationships with surrounding vascular cells, we confirmedVEGFC+,MFSD2A+, andACKR1+endothelium in arteries, capilla ...

identified two clusters ofDCN+andAPOD+ perivascular fibroblasts (Fig. 1, H and I). None of the perivascular fibroblasts expresse ...

Winkleret al.,Science 375 , eabi7377 (2022) 4 March 2022 5 of 12 A Vascular Neurons/glia Immune Endothelial Smooth muscle Fibrob ...

(fig. S11G). Vessel-associated CD11c+antigen- presenting cells are potent activators of brain CD4+T cell responses in situ ( 58 ...

Winkleret al.,Science 375 , eabi7377 (2022) 4 March 2022 7 of 12 CD79BIGLC2CD3DCCR7IKZF2IL2RACD8ACD8BGZMBGNLYMKI67TOP2AJCHAINCD1 ...

were angiographically confirmed preopera- tively, and fresh tissues were acquired as part of planned surgical resection. For scR ...

information for all tissues utilized is summar- ized in table S1. Isolation of cerebrovascular specimens No differences in vascu ...

containing 0.2% gelatin, 1% donkey serum, and 1% triton for 1 hour at room temperature and incubated in the following primary an ...

corrected embeddings. dittoSeq was used for color-blind friendly plotting ( 80 ). CellChat was used to infer cell communication ...

M. T. Lawtonet al., Brain arteriovenous malformations.Nat. Rev. Dis. Primers 1 , 15008 (2015). doi:10.1038/nrdp.2015.8; pmid: 2 ...

RESEARCH ARTICLE SUMMARY ◥ PLANT SCIENCE A conserved superlocus regulates above- and belowground root initiation Moutasem Omary† ...

RESEARCH ARTICLE ◥ PLANT SCIENCE A conserved superlocus regulates above- and belowground root initiation Moutasem Omary^1 †, Naa ...

with an initiation program that distinguishes it from lateral roots. Single-cell profiling reveals transitional cell state To fo ...

later stages of meristem initiation. By contrast, one-third of stage 1 cells were classified as phloem parenchyma or phloem, con ...

was previously reported ( 37 ), class IB LBDs form five distinct subclasses with subclass- specific protein motifs (fig. S10). S ...

were transiently induced in the hypocotyl after removal of the root system [Fig. 3R; ( 42 )]. Both CRISPR-generated nulllbd17and ...

this hypothesis, we generated a transcriptional time series of tomato lateral root initiation (Fig. 1, Q to V, and fig. S14A). B ...

K. Sugimoto, S. P. Gordon, E. M. Meyerowitz, Regeneration in plants and animals: Dedifferentiation, transdifferentiation, or ju ...