Science - USA (2022-04-08)

goal of achieving superior catalysts with sim- ultaneously high activity, selectivity, and stability. Understanding synthesis-st ...

development, continued efforts are needed in many areas, such as synthesis methodologies, advanced characterization, fundamental ...

6407 – 6413 (2020). doi:10.1021/acsnano.0c03993; pmid: 32469489 B. Jianget al., High-entropy-stabilized chalcogenides with high ...

with solid solution phases.Nat. Commun. 6 , 6529 (2015). doi:10.1038/ncomms7529; pmid: 25739749 S. Nellaiappanet al., High-entr ...

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RESEARCH ARTICLE SUMMARY ◥ CANCER GENOMICS Genome-wide analysis of somatic noncoding mutation patterns in cancer Felix Dietlein, ...

RESEARCH ARTICLE ◥ CANCER GENOMICS Genome-wide analysis of somatic noncoding mutation patterns in cancer Felix Dietlein1,2, Alex ...

Dietleinet al.,Science 376 , eabg5601 (2022) 8 April 2022 2 of 12 mutations / Mb (Lung) mutations / Mb (Lung) test 1 based on co ...

of mutation events, and a comparison with al- ternative implementations (figs. S13 to S17). A genome-wide compendium of mutation ...

them as being the result of a transcription- related mutational process ( 9 ), and other studies arrived at different conclusion ...

cancer gene) in esophageal cancer;KCNJ15(po- tassium channel) in kidney cancer;TCL1A,BCR, andNFKBIE(known cancer genes) in leuke ...

and genes where this localized mutation pat- tern occurred. Finally, we explored whether characteriz- ing mutation events around ...

regulatory category (fig. S39A), mainly in two binding motifs (81.8%; 9/11): Mutations in the ELK4motif produced two binding sit ...

andFGFR2in lung cancer (P=9×10−^4 and 1 × 10 −^2 , respectively),ARRDC3in kidney cancer (P=4×10−^2 ),PIK3C2Bin bladder cancer (P ...

biological relevance of mutation events out- side of canonical regulatory regions (Fig. 5 and figs. S49 to S55). As a first expe ...

tiles the genome with multiple interval sizes. This proved critical for its use and perform- ance in the noncoding genome, which ...

data ( 7 )] that allows for nonexponential rela- tionships between mutation rates and epige- nomic signals. Significance test 2 ...

D. Szklarczyket al., The STRING database in 2017: Quality- controlled protein-protein association networks, made broadly access ...

RESEARCH ARTICLE SUMMARY ◥ IMMUNOGENOMICS Single-cell RNA-seq reveals cell typeÐspecific molecular and genetic associations to l ...

RESEARCH ARTICLE ◥ IMMUNOGENOMICS Single-cell RNA-seq reveals cell typeÐspecific molecular and genetic associations to lupus Ric ...