Cell - 8 September 2016
cells, whereas in absence ofgdT cells PD-L1 or Galectin-9 blockade offers no additional tumor-protective benefit. Even more, PD- ...
colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell 21 , 822–835. Bed ...
promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature 532 , 245–249. Sharma, P., and Allison, ...
STAR+METHODS KEY RESOURCES TABLE REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies InVivomAb Anti-mouse TCR Vg 2 BioXCell Clone:U ...
Continued REAGENT or RESOURCE SOURCE IDENTIFIER FC: anti-mouse ICOS Biolegend Clone: 15F9 FC/IF: anti-mouseabTCR Biolegend Clone ...
CONTACT FOR REAGENT AND RESOURCE SHARING Further information and requests for reagents may be directed to and will be fulfilled ...
were collected under an IRB approved protocol and donors of de-identified specimens gave informed consent. Sample sizes for hu- ...
465/30, 520/30, 575/70, and 660/50 nm band-pass filters and nondescanned detectors to generate second harmonic signals (collagen ...
Supplemental Figures Figure S1. PDA-InfiltratinggdT Cells Express Elevated FoxP3, Related toFigure 2 (A and B) WT mice were orth ...
Figure S2.gdT Cells in Pancreata of KC Mice Exhibit a Distinct Phenotype, Related toFigure 2 (A) Single cell suspensions of panc ...
Figure S3. Selective Blockade of Chemokine Signaling MitigatesgdT Cell Expansion and Activation in PDA and Deletion or Depletion ...
Figure S4.gdT Cells Do Not Directly Modulate Pancreatitis or Transformed Epithelial Cells, Related toFigure 3 (A) Acute pancreat ...
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Figure S5.gdT Cell Deletion Results in MarkedabT Cell Expansion and Activation in a Slowly Progressive Model of PDA, Related toF ...
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Figure S6. PDA-InfiltratinggdT Cells InhibitabT Cells but Exhaustion Ligand Blockade Is Tumor Protective and Activates CD8+T Cel ...
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Figure S7.gdT Cells Do Not Alter Myeloid Cell Infiltration or Function in PDA and Localize withabT Cells in the TME, Related toF ...
Article A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells Graphical Abstract Highli ...
Article A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells Meromit Singer,1,6Chao Wa ...
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