Science - USA (2022-04-15)
R. R. Driskell, F. M. Watt, Understanding fibroblast heterogeneity in the skin.Trends Cell Biol. 25 , 92–99 (2015). doi:10.1016 ...
L.C. developed the idea, conducted the experiments, and wrote the manuscript. I.K. participated in the development of the idea, ...
RESEARCH ARTICLE SUMMARY ◥ NEUROIMMUNOLOGY Bacterial sensing via neuronal Nod2 regulates appetite and body temperature Ilana Gab ...
RESEARCH ARTICLE ◥ NEUROIMMUNOLOGY Bacterial sensing via neuronal Nod2 regulates appetite and body temperature Ilana Gabanyi1,2, ...
Gabanyiet al.,Science 376 , eabj3986 (2022) 15 April 2022 2 of 12 Thalamus Hypothalamus AB NeuN Iba1 Overlay C D Nod2 GFP Nod2 G ...
period of several months,VgatDNod2females gained more weight than didNod2floxand Vgatcrecontrols (Fig. 2A). Weight differences b ...
than in control mice (Fig. 2H and fig. S4F). Moreover, femaleVgatDNod2mice showed de- layed temperature drops in response to fas ...
sphingosine-1-phosphate released under cellu- lar stress conditions ( 31 ). The lack of Nod2 in inhibitory neurons had particula ...
intestinal and blood-brain barrier permeability, as well as microbiota composition—are also likely to play a role ( 32 , 37 – 39 ...
Gabanyiet al.,Science 376 , eabj3986 (2022) 15 April 2022 7 of 12 GH DMH ARC ROSAYFP I ** ** K CRE virusNod2flox CRE vir ...
decrease (as observed in pre-menopausal and menopausal states), this control of food intake would be attenuated and MDP’s ano- r ...
were gavaged with 60,000 cpm of^14 C-GlcNAc- labeled PG. Control mice were gavaged with the equivalent dilution of nonlabeled PG ...
Roche). For insulin measurements, samples were immediately placed on ice and centri- fuged at 14,000gfor 10 min at 4°C as soon a ...
Slices were visualized using a 40× water im- mersion objective (Zeiss Achroplan 440090; NA 0.75; no aberration correction; worki ...
R. D. Lisk, R. A. Pretlow 3rd, S. M. Friedman, Hormonal stimulation necessary for elicitation of maternal nest-building in the ...
RESEARCH ARTICLE SUMMARY ◥ SIGNAL TRANSDUCTION Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of ...
RESEARCH ARTICLE ◥ SIGNAL TRANSDUCTION Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1 ...
diet [the fructose, palmitate, and cholesterol (FPC) diet] (Fig. 1H). Phosphorylation of S6 was unchanged in mice fasted overnig ...
FLCN binds to and inhibits or activates adenosine monophosphate–activated protein kinase (AMPK) in various cell types ( 24 – 26 ...
Loss of FLCN in the liver suppresses de novo lipogenesis We had expected thatFlcndeletion would promote lysosomal and mitochondr ...
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