Organ Regeneration Based on Developmental Biology

49 corticotroph differentiation efficiency was decreased, and other lineages were not detected. Previous reports have shown that ...

50 Fig. 3.3 Functional tests of mouse ES-derived ACTH+ cells. (a) In vitro release from mouse ES-derived ACTH+ cells. “F” = gluc ...

51 3.11 Effect of Transplantation into Hypophysectomized Model Animals Finally, we evaluated the transplantation effect of the i ...

52 The characteristics for differentiating pluripotent stem cells into pituitary cells were as follows: Simultaneous induction ...

53 or small molecule agonists. However, ectopic transplantation is not perfect, because physiological CRH released from the hypo ...

54 In future studies, it will be challenging to recapitulate an entire anterior pituitary gland that contains all endocrine comp ...

55 Fauquier T, Guérineau NC, McKinney RA et al (2001) Folliculostellate cell network: a route for long-distance communication in ...

56 Nakano T, Ando S, Takata N et al (2012) Self-formation of optic cups and storable stratified neural retina from human ESCs. C ...

© Springer Nature Singapore Pte Ltd. 2017 57 T. Tsuji (ed.), Organ Regeneration Based on Developmental Biology, DOI 10.1007/978- ...

58 semicircular canals and the maculae of the utricle and saccule (Fig. 4.1). Key to the function of both the auditory and vesti ...

59 The differentiation of embryonic stem cells (ESCs) into inner ear organoids comprising sensory epithelia, including hair cell ...

60 embryos demonstrates that early BMP signaling during gastrulation induces four transcription factors (Tfap2a, Tfap2c, Foxi1, ...

61 et al. 2005 ; Pieper et al. 2012 ; Saint-Jeannet and Moody 2014 ). The cranial placodes are arranged anteroposteriorly, and t ...

62 4.3 Generation of Inner Ear Organoids One of the earliest protocols for differentiation of mouse embryonic stem cells (ESCs) ...

63 (derived from that anterior aspect of the PPR) has been documented. After NNE formation, treatment with the medium that did n ...

64 signaling—this was recapitulated in vitro in the experiments to induce anterior pitu- itary gland tissue from floating ESC ag ...

65 is apparently contingent on internal FGF signaling; this was proven when applica- tion of the FGF inhibitor SU5402 prohibited ...

66 central core of the aggregate. Between days 9 and 12, continuous evagination of vesicles into the outer cell layer occurs (Fi ...

67 The next step was to determine the type of hair cells arising in our culture. Co-expression of Pax2 and Sox2 has been shown t ...

68 The inner ear organoid can also serve as a potent model system to study patho- physiology of various forms of hereditary inne ...