Imaging in Stem Cell Transplant and Cell-based Therapy
76 In order to achieve a quicker hematopoietic recovery and prevent infectious and bleeding complications after HDchemotherapy, ...
77 relevance of ASCT in treatment of MM [ 33 ]. IMiDs and proteasome inhibitors are the most frequently used agents for inductio ...
78 5.2.4 ASCT in Relapsed MM In relapsed MM, HDchemotherapy with ASCT is an established treatment regimen that needs to be cons ...
79 randomized, openlabel, phase III NCRI Myeloma X Relapse trial similar findings were noted, showing that myeloma patients who ...
80 5.3 Mobilization and Collection of Peripheral Blood Stem Cells It is general consensus that circulating peripheral CD34+ bloo ...
81 maintenance therapy (Fig. 5.2.). In the first TT1 trial started in 1990 only conven tional chemotherapy was used, in TT2(a) ...
82 significant differences in OS were noted between patients who underwent tandem ASCT and ASCT/AlloSCT [ 65 ]. In contrary, lo ...
83 Lonial S, Dimopoulos M, Palumbo A, White D, Grosicki S, Spicka I, et al. Elotuzumab ther apy for relapsed or refractory mul ...
84 Barlogie B, Jagannath S, Desikan KR, Mattox S, Vesole D, Siegel D, et al. Total therapy with tandem transplants for newly di ...
85 Cook G, Williams C, Brown JM, Cairns DA, Cavenagh J, Snowden JA, et al. Highdose che motherapy plus autologous stemcell t ...
86 Franssen LE, Raymakers RA, Buijs A, Schmitz MF, van Dorp S, Mutis T, et al. Outcome of allogeneic transplantation in newly d ...
© Springer International Publishing AG 2017 87 T. Pandey (ed.), Imaging in Stem Cell Transplant and Cell-based Therapy, Stem Cel ...
88 6.1 Introduction MM is a malignancy of terminally differentiated B cells characterized by a clonal proliferation of plasma ce ...
89 and labor intensive to attempt luciferase transfection. Although enzyme-linked immunosorbent assay (ELISA) for human immunogl ...
90 severe-combined immunodeficient (SCID) or non-obese diabetic-SCID mice with a defect in the IL2 receptor gamma chain (NOD/SCI ...
91 6.2.3 Bioluminescence Imaging In recent years, bioluminescence imaging (BLI) has drawn much attention and is commonly used in ...
92 quantification of the tumor burden in humanized models (Fig. 6.3) [ 18 , 22 ]. A decrease in emission of photons is attribute ...
93 high-risk myeloma at our center [ 18 ]. Unfortunately, this technique also has some limitations. The intensity of photon emis ...
94 Fig. 6.4 MRI visualizing tumor growth and effect of Exp-NK cells in myelomatous mouse. NOD/ SCID/IL2Rγnull-hu mice were engra ...
95 bone integrity after successful ENK cell therapy in myelomatous mice (Fig. 6.4). Although MRI is a useful imaging technique, ...
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