Science - USA (2022-04-29)
trait) were enriched for SNPs associated in any of the 119 behavioral GWASs (fig. S31). Only one GWAS (Q66,“lifts leg to urinate ...
53.0 ± 30.2% (±SD) of heritability is attribut- able to associated SNPs (p<1×10−^6 ), but for the eight behavioral factors an ...
questions from published and validated sur- veys: (i) Dog Personality Questionnaire (DPQ/ DPQL; 45 questions) ( 37 ); (ii) Canin ...
event that occurred, on average, once every Morgan. Simulations ran on 10 independently drawn datasets of six dogs per reference ...
Genetic differentiation of breeds We calculated genome-wide normalized PBS scores using the Hudson estimator of fixation (FST) f ...
J. A. Kernset al., Linkage and segregation analysis of black and brindle coat color in domestic dogs.Genetics 176 , 1679 – 1689 ...
Publishyourresearch intheSciencefamilyofjournals TheSciencefamilyofjournals(Science, Science Advances,ScienceImmunology, Science ...
RESEARCH ARTICLES ◥ CANCER Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress Brian D ...
native bromodeoxyuridine (BrdU) and rep- lication protein A (RPA) foci formation. Both approaches demonstrated elevated numbers ...
478 29 APRIL 2022¥VOL 376 ISSUE 6592 science.orgSCIENCE NT 1h 3h 6h 24h CAD ICAD-L p53 H3 IR (8Gy) Chromatin Fraction A TUNEL mC ...
SCIENCEscience.org 29 APRIL 2022¥VOL 376 ISSUE 6592 479 5000 10000 15000 20000 RFI 0 5 10 15 20 25 0 Time (min) mCherry- ICAD GF ...
(TUNEL) (Fig. 2B). Activation of the DNA dam- age response was noted by increased RPA association, ATR (ataxia telangiectasia an ...
checkpoint. We confirmed premature mitotic entry observed in the siRNA-based screen using individual siRNAs targeting CAD and IC ...
active CHK1 (fig. S10, A to E). CDK1 inhi- bition is required to restrict mitotic entry after IR. Additionally, activated CHK2 a ...
M. T. Dillon, J. S. Good, K. J. Harrington,Clin. Oncol. 26 , 257 – 265 (2014). A. Cieślar-Pobuda, Y. Saenko, J. Rzeszowska-Woln ...
is encoded by slow-acting neuropeptides in C fibers and their cognate excitatory G protein– coupled receptors (GPCRs) in laminae ...
NK1R—two markers expressed in distinct sub- sets of projection neurons—implicated in af- fective touch and pain, respectively ( ...
anxiety associated with handling. First, given that social isolation increases the urge for social touch and attachment ( 26 ), ...
2 days) using an unbiased two-chamber pleas- ant touch–conditioned place preference (PT- CPP) apparatus in which WT mice display ...
Neurophysiological features of PROKR2 neurons in response to varying stimuli To interrogate neural correlates of pleasant touch, ...
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