Resistant Hypertension in Chronic Kidney Disease
126 Cao Y, Tao L, Yuan Y, Jiao X, Lau WB, Wang Y, et al. Endothelial dysfunction in adiponectin deficiency and its mechanisms i ...
© Springer International Publishing AG 2017 127 A. Covic et al. (eds.), Resistant Hypertension in Chronic Kidney Disease, DOI 10 ...
128 hypertension is critical for the management of hypertension in CKD. However, there are large gaps in our understanding of p ...
129 The kidney acts as an excretory organ, a component in the sympathetic axis, and a source of circulating constrictors and dil ...
130 A reduced number of nephrons have been proposed as one of the factors contrib- uting to the development of primary hypertens ...
131 The Central Role of the Renin-Angiotensin-Aldosterone System The RAAS has powerful effects on control of the blood pressure ...
132 Sympathetic Nervous System Increased SNS activity is an important volume-independent cause in pathophysiol- ogy of hypertens ...
133 Endothelins Endothelins are produced primarily by cells of the vascular endothelium and col- lecting tubules. Endothelin-1 e ...
134 Miscellaneous Other Non-humoral Factors Mineral and Bone Disorders The progression of CKD is associated with disorders of mi ...
135 stimulate vascular contraction directly through decreasing local NO production or modulate central SNS activation. Drugs Sev ...
136 Kanbay M, Turgut F, Uyar ME, Akcay A, Covic A. Causes and mechanisms of nondipping hypertension. Clin Exp Hypertens. 2008; ...
137 Converse RL, Jacobsen TN, Toto RD, Jost CM, Cosentino F, Fouad-Tarazi F, et al. Sympathetic overactivity in patients with c ...
© Springer International Publishing AG 2017 139 A. Covic et al. (eds.), Resistant Hypertension in Chronic Kidney Disease, DOI 10 ...
140 goal of less than 150/90 mmHg for hypertensive persons aged 60 years or older and for hypertensive persons 30–59 years of ag ...
141 an inflammatory process and may lead to fragmentation of elastic membranes and destruction of cell-protective matrix layers. ...
142 Typical values of PWV in the aorta range from approximately 5 to >15 m/s. A fixed threshold value (12 m/s) was proposed ...
143 mean arterial pressure or peripheral pulse wave velocities. Moreover, each 0.1 increase in renal resistive index was associa ...
14 4 Fig. 9.1 Work-up for hypertension and CKD patient. HTN hypertension, CKD chronic kidney disease, BP blood pressure, eGFR es ...
145 disease) and for CKD on KDIGO (Kidney Disease: Improving Global Outcomes) classification based on estimated glomerular filtr ...
146 Development of combination therapies with diuretics and/or calcium channel blockers [ 4 ] Specific interventions, such as r ...
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