Computational Systems Biology Methods and Protocols.7z

3.1 The Polymerase Chain Reaction The polymerase chain reaction (PCR) is the most common meth- odology, but alternatives are het ...

4 Interferon-Gamma Activity and Interferon-Gamma Release Assays (IGRAs) Interferon-gamma release assays (IGRAs) are whole-blood ...

for diagnosing TBM. Standardized cutoffs of ADA values for the diagnosis of TBM have not been established, and the values used i ...

associated with leptomeningeal enhancement in TBM. The exudate at the basal region surrounds the arteries, leading to arterial n ...

possible tuberculous meningitis diagnostic criteria [7]. According to Thwaites criteria, definite, probable, or possible TBM is ...

adolescents and adults. N Engl J Med 351 (17):1741–1751 Sutlas PN et al (2003) Tuberculous meningitis in adults: review of 61 c ...

Helb D et al (2010) Rapid detection of Myco- bacterium tuberculosis and rifampin resistance by use of on-demand, near-patient t ...

Thwaites GE et al (2002) Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. Lancet 360 (9342 ...

Chapter 21 Insights of Acute Lymphoblastic Leukemia with Development of Genomic Investigation Heng Xu and Yang Shu Abstract Trea ...

rates have risen from less than 10% in the 1960s to around 90% today primarily due to the drug development as well as risk-adapt ...

chain reaction (PCR)/real-time PCR, genome/transcriptome microarray technology, and next-generation sequencing [11, 19]. Additio ...

classifications such as risk group determination. Most of the anti- leukemic drugs are developed from the 1950s through the 1980 ...

3% in children to 20% in adults and more than 50% in patients older than 50 years old [6, 21, 25]. However, patients with t(1;19 ...

On the other hand, inherited genetic variants were also consid- ered to be involved in treatment outcomes, especially for advers ...

whole TMPT genes by using Sanger sequencing [33]. This finding has been successfully translated into clinical practice for dosag ...

as many as possible, the probes are designed to be nearly evenly distributed across the genome [45] and mostly target the SNPs w ...

study-specific analyses which depend on the experiment design. Take microarrays from Affymetrix as examples; SNP genotype calls ...

daunorubicin) and higher risk of relapse than other subtypes, which is similar as that for BCR-ABL1 positive patients [68]. Howe ...

occur in the early step of ALL leukemogenesis and mostly cooper- ate with additional oncogenic events afterward. Meanwhile, alte ...

however, with varied odds ratio (OR) in terms of different ethni- cities, ages, and ALL subtypes. For instance: 1.ARID5BandPIP4K ...