Computational Systems Biology Methods and Protocols.7z

functional experiments, NUDT15 was firstly reported to be involved in metabolic pathway of mercaptopurine, and the risk allele o ...

3.7 Remained Questions Although the microarray-based genome-wide investigation is effec- tive and informative, these approaches ...

The short-read sequencing platforms can be divided into two major approaches: sequencing by ligation (SBL) and sequencing by syn ...

expression of mRNA or noncoding RNA, both of which show important roles in tumor biology; meanwhile, fusion gene can also be ide ...

4.3 Genetic Characteristics and the Related NGS-Based Genomic Technologies Extensive efforts have been made to comprehensively u ...

With the sharply decreased cost of sequencing and the improvement of bioinformatics analyses (both the computer power as well as ...

PRPS1) [164, 170–172], which can validate the subsequent drug resistance analyses in cellular level. NGS-based GWASs become more ...

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Ionita-Laza I et al (2013) Sequence kernel association tests for the combined effect of rare and common variants. Am J Hum Gene ...

INDEX A Accuracy (ACC)..................................................4, 40, 55, 57, 59, 79, 86, 89, 116, 120, 140, 188, 192, ...

Genome-wide association study (GWAS)............97–106, 394, 395, 397–399, 405 Gini correlation coefficient (GCC)............... ...

R Random forest (RF)......................................86,190–192, 194, 228, 250, 252, 255, 258 Random walk with restart (RWR ...