Science - 16.08.2019
respectively, might also counteract this inexora- ble mutation accumulation in somatic cells. Quality control processes to cope ...
dislodge at least some tail-anchored proteins, such as Pex15, from the outer mitochondrial membrane, allowing protein retargetin ...
phagocytosed DNA is recognized by TLR9 ( 53 – 55 ). Viral double-stranded RNA (dsRNA) is recognized by the relatives RIG I and M ...
and inflammation ( 79 ). A well-characterized path- way that selectively removes damaged mitochon- dria involves the ubiquitin k ...
M. Koppen, T. Langer, Protein degradation within mitochondria: Versatile activities of AAA proteases and other peptidases. Crit ...
M. P. Giannoccaro, C. La Morgia, G. Rizzo, V. Carelli, Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson’s d ...
RESEARCH ARTICLE SUMMARY ◥ IMMUNE SIGNALING Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses ...
RESEARCH ARTICLE ◥ IMMUNE SIGNALING Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses Lei Wang ...
expression were unaffected (fig. S3, A and B). Thus, hnRNPA2B1 initiates IFN-I responses to DNA viruses in both mouse and human ...
carrying mutations in the dimer interface could not rescue HSV-1–inducedIfnb1mRNA expres- sion (Fig. 3D) or activation of anIfnb ...
macrophages (fig. S8I), excluding the possibil- ity that this was due to the reduced entry of HSV-1 into macrophages. Thus, Src ...
HSV-1–inducedIfnb1transcription was atte- nuated inHnrnpa2b1-KO PMs (Fig. 6C). Vaccinia virus (VACV), another DNA virus, replica ...
receptor activity and electron transfer activity (fig. S13A). Several immune-associated genes includingCgasandStingmRNAs were re ...
response pathways in innate immunity and inflammation. cGAS has been shown to have an essential role for innate response to path ...
recognition remain open questions. Further- more, the differences between the DNA- and RNA-binding activities of hnRNPA2B1 are s ...
(Gibco). Mouse peritoneal macrophages were iso- lated from the peritoneal cavities of mice 3 days after injection with thioglyco ...
HSV-1 entry detection Mouse peritoneal macrophages were treated with or without Src inhibitor for 30 min and infected with HSV-1 ...
Lupus 22 , 607–613 (2013). doi:10.1177/0961203313484978; pmid: 23612796 R. Fritsch-Storket al., The spliceosomal autoantigen he ...
RESEARCH ARTICLE SUMMARY ◥ NEUROSCIENCE Hippocampal sharp-wave ripples linked to visual episodic recollection in humans Yitzhak ...
RESEARCH ARTICLE ◥ NEUROSCIENCE Hippocampal sharp-wave ripples linked to visual episodic recollection in humans Yitzhak Norman^1 ...
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