Nature 2020 01 30 Part.02

A lthough it happened almost a decade ago, Willem de Vos still vividly remem- bers his colleagues being told to halt the clinica ...

interact to produce substances or behaviours for medical benefit. Both approaches are in their infancy, and there are challenges ...

or degrading a toxin. Creating new functions requires designing from the bottom up — testing different combinations of microbes, ...

UCSF “The research questions pertaining to diet and the gut microbiome are wide open.” Peter J. Turnbaugh is a microbiologist at ...

Villi of the small intestine are home to gut microbes. Research round-up Microbe boosts metabolic health According to a clinical ...

Weight loss without microbial gains French scientists have examined the microbiomes of people with severe obesity, and how the c ...

Article https://doi.org/10.1038/s41586-019-1237-9 Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases Jaso ...

reSeArcH Article epigenetic reduced representation bisulfite sequencing (RRBS), and 16S rRNA gene amplicon sequencing (16S), whi ...

Article reSeArcH functions in the gut^15. Notably, nicotinuric acid, a metabolite of nicotinate^16 , was found almost exclusivel ...

reSeArcH Article with demographics or medication (logistic regression with subject as random effect, all FDR P > 0.05). Dysbi ...

Article reSeArcH an unknown feature with m/z of 648.43067 and RT of 5.03 min, contrib- uted the most (ten) shifts exclusively in ...

reSeArcH Article To identify the components of the microbiome that were most asso- ciated with these changes, we tested for tran ...

Article reSeArcH Representatives from the five stool-derived measurements occurred as hubs (defined as nodes with at least 20 co ...

reSeArcH Article Ananthakrishnan, A. N. Environmental risk factors for inflammatory bowel diseases: a review. Dig. Dis. Sci. 60 ...

Article reSeArcH MEthODS Recruitment and specimen collection. Recruitment. Five medical centres partici- pated in the IBDMDB: Ci ...

reSeArcH Article Sequencing assays. DNA and RNA isolation for metagenomics and metatranscrip- tomics. Total nucleic acid was ext ...

Article reSeArcH acquisition rate. Additional MS settings are: ion spray voltage, –3.5 kV; capillary temperature, 320 °C; probe ...

reSeArcH Article palindromic forked adapters with unique 8-base index sequences embedded within the adaptor and added to each en ...

Article reSeArcH subject for variables that change over time (medication, biopsy location, inflam- mation status, and dysbiosis) ...

reSeArcH Article We then compared these dysbiosis classifications with those from the nearest metagenomic sample (up to two week ...