Nature - USA (2020-01-02)
Nature | Vol 577 | 2 January 2020 | 121 Article Impaired cell fate through gain-of-function mutations in a chromatin reader Lili ...
122 | Nature | Vol 577 | 2 January 2020 Article (human kidney-2) cells that stably expressed wild-type ENL or one of three disti ...
Nature | Vol 577 | 2 January 2020 | 123 the YEATS domain, which is important for ENL to localize to chroma- tin^1 ,^4 , we first ...
124 | Nature | Vol 577 | 2 January 2020 Article pocket (Fig. 3a). As such, we wondered whether ENL T mutants could bypass the ac ...
Nature | Vol 577 | 2 January 2020 | 125 mCherry eYFP–LacI WT WT T1 T2 T3 T1 T2 T3 WT LacI alone T1 T2 T3 d e j f g hi a c b WT T ...
126 | Nature | Vol 577 | 2 January 2020 Article in gene activation, further strengthening the conclusion that AHD- mediated inte ...
Reporting summary Further information on research design is available in the Nature Research Reporting Summary linked to this pa ...
Article Extended Data Fig. 1 | See next page for caption. ...
Extended Data Fig. 1 | ENL mutations induce transcriptional changes that are implicated in developmental programs and in Wilms t ...
Article Extended Data Fig. 2 | Three-dimensional nephron structures derived from mESCs. a, Diagram showing the in vitro directed ...
Extended Data Fig. 3 | Characterization of ENL-mutant kidney structures. a, d, g, Representative haematoxylin and eosin staining ...
Article Extended Data Fig. 4 | ENL mutants occupy largely the same genomic loci as the wild-type protein. a, b, Bar graphs showi ...
Extended Data Fig. 5 | Enhanced occupancy of ENL mutants at a shared subset of target genes correlates with gene activation. a, ...
Article Extended Data Fig. 6 | Enhanced binding of ENL mutants at target genes leads to increased SEC recruitment and activity. ...
Extended Data Fig. 7 | Loss of PAF1 has minimal effect on the functionality of cancer-associated ENL mutants. a, Western blot an ...
Article Extended Data Fig. 8 | Interaction with histone acylation is essential but not sufficient for chromatin occupancy by can ...
Extended Data Fig. 9 | See next page for caption. ...
Article Extended Data Fig. 9 | Characterization of nuclear puncta formed by ectopically expressed ENL tumour mutants. a, Fractio ...
1 nature research | reporting summary October 2018 Corresponding author(s): Liling Wan, Hong Wen, C. David Allis Last updated by ...
2 nature research | reporting summary October 2018 For a reference copy of the document with all sections, see nature.com/docume ...
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