Nature - USA (2020-01-02)
106 | Nature | Vol 577 | 2 January 2020 Article RIPK1 cleavage limits TNF-induced cell death To explore the function of RIPK1 cl ...
Nature | Vol 577 | 2 January 2020 | 107 cells, RIPK1 also contributes to the activation of NF-κB and MAPK signalling pathways^14 ...
108 | Nature | Vol 577 | 2 January 2020 Article Cuchet-Lourenço, D. et al. Biallelic RIPK1 mutations in humans cause severe imm ...
Methods Participant enrolment Families were enrolled and evaluated in the Clinical Center at the National Institutes of Health u ...
Article of imaging. For the Opera Phenix imaging, images were analysed using the server-based Columbus 2.8.0 software (PerkinElm ...
for clinical and technical assistance, C. Liegeois for IT assistance and the staff of the WEHI Bioservices facility for mouse hu ...
Article Extended Data Fig. 1 | Inf lammatory gene signature in P7 whole-blood RNA. a, MA plot between two P7 samples and two unr ...
Extended Data Fig. 2 | Exome reads in family 1. Excerpts of coverage histograms and aligned exome sequence reads for the proband ...
Article Extended Data Fig. 3 | ‘Kinase-dead’ RIPK1 or combined loss of Ripk3 and Casp8 rescue Ripk1D325A/D325A lethality. a, b, ...
Extended Data Fig. 4 | Ripk1D325A/+ cells are hypersensitive to TNF-induced death. a–c, MDFs (a), BMDMs (b) and MEFs (c) of the ...
Article Extended Data Fig. 5 | Alternative cleavage of RIPK1. a, MEFs were treated with 10 ng ml−1 TNF combined with 500 nM SMAC ...
Extended Data Fig. 6 | RIPK1 cleavage limits inf lammation in an NF-κB- independent manner. a, Serum cytokine levels in wild-typ ...
Article Extended Data Fig. 7 | See next page for caption. ...
Extended Data Fig. 7 | Proposed model for RIPK1(D325A)-induced cell death. Left, TNF binding to TNFR1 triggers the formation of ...
Article Extended Data Table 1 | Leukocyte surface markers in patients with CRIA syndrome Percentages before tocilizumab treatmen ...
Extended Data Table 2 | Effect of tocilizumab treatment and RIPK1 caspase cleavage site mutations is absent in known autoinflamm ...
Article Extended Data Table 3 | Conservation of RIPK1 caspase-8 cleavage site Protein sequences orthologous to human RIPK1 were ...
1 n at ur e r es e ar c h | r e p orti n g s u m m ar y O ct o b er 2 0 1 8 C orr es p o n di n g a ut h or(s): N aj o u a L al ...
2 nature research | reporting summary October 2018 Data Policy information about availability of data All manuscripts must inclu ...
3 nature research | reporting summary October 2018 IκBα (cat number 9242, Cell Signaling Technology) phospho-p65 (clone 93H1, ca ...
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