Nature - USA (2020-01-02)
3 nature research | reporting summary October 2018 Reporting for specific materials, systems and methods We require information ...
Nature | Vol 577 | 2 January 2020 | 95 Article Prevention of tuberculosis in macaques after intravenous BCG immunization Patrici ...
96 | Nature | Vol 577 | 2 January 2020 Article (5 × 10^5 CFUs; AE/ID) (Extended Data Fig. 1a). Immune responses and protective e ...
Nature | Vol 577 | 2 January 2020 | 97 h –log ( 10 P value) log 2 -transformed fold change 0 100 200 300 400 −2 −1 0 1 2 TNFSF8 ...
98 | Nature | Vol 577 | 2 January 2020 Article showed that the IV-BCG-immunized group had lower gross pathol- ogy scores^27 (Fig ...
Nature | Vol 577 | 2 January 2020 | 99 (Fisher’s exact test, P < 10−4) at any given threshold less than 10,000 CFUs (Extended ...
100 | Nature | Vol 577 | 2 January 2020 Article and a trend towards increased survival was reported after IV BCG immu- nization ...
Nature | Vol 577 | 2 January 2020 | 101 mediate control against Mtb in vivo or in vitro^39 ,^40. Antibody levels were higher in ...
102 | Nature | Vol 577 | 2 January 2020 Article World Health Organization. Global Tuberculosis Report https://www.who.int/tb/ p ...
Methods Macaques and sample size Indian-origin rhesus macaques (Macaca mulatta) used in these studies are outlined in Extended D ...
Article Rhesus blood, BAL and tissue processing Blood PBMCs were isolated using Ficoll-Paque PLUS gradient separa- tion (GE Heal ...
96-well MaxiSorp ELISA plates (Nunc) were coated overnight at 4 °C with 0.1 μg of WCL. Plates were blocked with PBS/FBS (10%) fo ...
Article provides regression analyses that support Extended Data Fig. 13. Sup- plementary Tables 2–4 include stimulation-inducibl ...
Extended Data Fig. 1 | Study design, vaccine regimens, macaques and cohorts. a, Vaccine groups including route of BCG administra ...
Article Extended Data Fig. 2 | Clinical parameters after BCG vaccination in NHPs. To assess safety of BCG vaccinations, all maca ...
n=11 2 3 3 3 3 11 12 11 11 7 4 7 4 4 4 4 3 4 4 4 Leukocytes in PBMCs NK pDC mDC B Mono T AE AE/ID IV ID low ID high P 2 4 8 12 1 ...
Article Extended Data Fig. 3 | Proportions of leukocyte and T cell subsets in the BAL and PBMCs after BCG immunization. a–d, We ...
Extended Data Fig. 4 | See next page for caption. ...
Article Extended Data Fig. 4 | Extended immune data from challenge and immunology cohorts. a, b, Full kinetics of PBMC responses ...
a b Total IL-17 (%) Pie colors IFN IL-2 TNF IFN IL-2 TNF CD154 IFN IL-2 TNF IFN IL-2 TNF CD4 Response (PBMCs) CD8 Response (PBMC ...
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