Nature - USA (2020-08-20)

Article Yang, W., Dierking, K. & Schulenburg, H. WormExp: a web-based application for a Caenorhabditis elegans-specific gen ...

Extended Data Fig. 1 | Absence of coelomocytes causes LBP-2 to accumulate in pseudocoelom together with secreted GFP. a, LBP-2:: ...

Article Extended Data Fig. 2 | RNAi targeting ECRs reproducibly enhances LBP-2 aggregation. a, Pie charts depict results from RN ...

Extended Data Fig. 3 | ECRs regulate LYS-7 aggregation. a, Quantification of animals without GFP-labelled coelomocytes in transg ...

Article Extended Data Fig. 4 | ECR overexpression effectively prevents extracellular protein aggregation. a, Overexpression of E ...

Extended Data Fig. 5 | Extracellular proteostasis inf luences ageing and is differentially regulated during ageing. a, F56B6.6-o ...

Article Extended Data Fig. 6 | Impairing extracellular proteostasis accelerates intoxication-related mortality. a, Expression le ...

Extended Data Fig. 7 | ECR overexpression does not induce a global immune response. Heat map of z-score-normalized expression da ...

Article Extended Data Table 1 | Lifespan assays Asterisk indicates siblings without the ECR overexpression. ...

Extended Data Table 2 | Survival assays on Cry5B Asterisk indicates siblings without the ECR overexpression. ...

Article Extended Data Table 3 | Survival assays on Cry5B and ECR RNAi ...

1 nature research | reporting summary April 2018 Corresponding author(s): Della C. David Reporting Summary Nature Research wishe ...

2 nature research | reporting summary April 2018 Data Policy information about availability of data All manuscripts must include ...

3 nature research | reporting summary April 2018 Animals and other organisms Policy information about studies involving animals; ...

Nature | Vol 584 | 20 August 2020 | 415 Article Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila Sar ...

416 | Nature | Vol 584 | 20 August 2020 Article activate ISCs after stress^11 ,^13. Six hours of 20HE feeding induced the Egfr l ...

Nature | Vol 584 | 20 August 2020 | 417 To confirm the source of endogenous ecdysone, we used ovary-specific Gal4 drivers^3 ,^7 ...

418 | Nature | Vol 584 | 20 August 2020 Article are driven by 20HE signalling from the ovaries to progenitor cells in the gut. G ...

Nature | Vol 584 | 20 August 2020 | 419 suppressed Hr3 activity (Extended Data Fig. 8j). Removing Eip75B or Broad from ISCs by m ...

Article Methods Drosophila stocks and cultures Drosophila melanogaster were raised on standard media and main- tained in incubat ...