Nature - USA (2020-10-15)

Article Extended Data Fig. 4 | Biochemical analysis of bacterial STING cyclic dinucleotide recognition specificity. a, b, Electr ...

d a c h 02468 0 500 1000 1500 2000 2500 Retention time (min) Absorbance 254 nm (mAU ) cADPr ADPr NAD+ NAM 01234567 0 100 200 300 ...

Article Extended Data Fig. 5 | Bacterial STING activation of TIR NADase activity. a, HPLC analysis of chemical standards separat ...

a hi 036912 0.0 0.5 1.0 1.5 Time(h) OD 600 induced, +NAM uninduced, +NAM uninduced,−NAM induced,−NAM SfSTING WT NAM supplementat ...

Article Extended Data Fig. 6 | Mutagenesis analysis of bacterial STING cyclic dinucleotide recognition and TIR activation. a, Ta ...

a k Apo 100 nm 3',3'-cGAMP 100 nm c-di-GMP 100 nm 2' ,3'-cGAMP 100 nm c-di-AMP 100 nm Apo 100 Å 3',3'-cGAMP 100 Å c-di-GMP 100 Å ...

Article Extended Data Fig. 7 | Conservation of oligomerization as a mechanism of STING activation. a–i, STING SEC-MALS analysis. ...

a Free c-di-GMP SfSTING Mutant:— WTR307E ,A 309R L201R, D203Δ L275–Q282 R Well STING–CDN Complex c 2.0 2.2 2.4 2.6 2.8 3. 0 0 25 ...

Article P139 P136 P135 P134 Unique proline-rich loop at TIR–TIR interface S. faeciumTIR (Predicted) P. denitrificans TIR E84E239 ...

b a Mus musculus Rattus norvegicus Homo sapiens Nematostella vectensis Crassostrea gigas Drosophila melanogaster Capnocytophaga ...

Article Extended Data Fig. 10 | Structure-guided analysis of STING phylogenetic conservation and cyclic dinucleotide recognition ...

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434 | Nature | Vol 586 | 15 October 2020 Article A STAT3 palmitoylation cycle promotes TH 17 differentiation and colitis Mingmin ...

Nature | Vol 586 | 15 October 2020 | 435 STAT3 is palmitoylated by DHHC7 Recruitment of STAT3 to the plasma membrane is essentia ...

436 | Nature | Vol 586 | 15 October 2020 Article the results suggest that DHHC7-catalysed palmitoylation promotes the membrane l ...

Nature | Vol 586 | 15 October 2020 | 437 APT2 depalmitoylates p-STAT3 APTs are involved in regulating the membrane localization ...

438 | Nature | Vol 586 | 15 October 2020 Article colitis in mice, an experimental model for IBD. ML349 (50 mg kg−1) was well-tol ...

Nature | Vol 586 | 15 October 2020 | 439 significantly decreased the levels of TH17 cells in mouse splenocytes (Fig. 4f). To pro ...

Article Methods Ethics approval The protocols for collection of human PBMCs from healthy participants in the study were approved ...