Medicinal Chemistry

4.3.5.2 Drugs Interfering with Catecholamine Metabolism This group of drugs consists primarily of compounds that block the enzym ...

Guanethidine, rarely used as a hypotensive drug, also causes some catecholamine depletion, but unlike reserpine it does not cros ...

4.3.5.5 Drugs Acting on Presynaptic Adrenergic Receptors As mentioned in section 4.3.3, there are two kinds of αreceptor in brai ...

any such group leads to an almost total loss of pharmacological action; alternatively, the resultant compound may become an anta ...

from the discussion above, clonidine and α-methyldopa act in the same way. Clonidine also abolishes symptoms of opiate withdrawa ...

epinephrine and norepinephrine, producing hypertension, accelerated heart rate, and cardiac arrhythmias in the patient. α-recept ...

Modification of the intermediate aminoethanol side chainbetween the catechol and the terminal amine can produce surprising effe ...

diameter, hindering air entry and promoting air trapping within the lungs); of these two groups, obstructive diseases are much m ...

Althoughβagonists also mediate metabolic effects, such as the conversion of glycogen to glucose (glycogenolysis) in both liver a ...

hydroxyls by chlorine atoms. However, DCI is also a partial βagonist, and therefore cannot be used as a hypotensive drug. Propra ...

mixture is used clinically. The different stereoisomers have varying activities as α andβ antagonists. All of the β-antagonist p ...

involves both manic and depressive episodes in the same person and is a biologically different disorder from a unipolar illness, ...

functions also act as antidepressants, as will be shown later. Thus, it is likely that endogenous depression is a biologically h ...

central brain structures showing specific DA receptors. Approximately 80% of DA receptors in the brain are localized in the corp ...

Parkinson’s disease-like movement disorders. Therefore, the motor dysfunctions observed in patients chronically treated with ant ...

The arylamino acid decarboxylase inhibitory action of DL-α-fluoromethyldopa (4.77) has also been described. By affecting the enz ...

4.4.3 Postsynaptic Dopaminergic Drug Effects 4.4.3.1 Dopamine Agonists Besides dopamine itself, several highly active DA agonist ...

vasodilator with central effects and has been advocated as a physical and mental geriatric performance enhancer. Other ergot alk ...

emotional response. Paranoid psychosis, on the other hand, is a psychotic disorder in which delusions, generally persecutory but ...

features: an affinity for 5-HT 2 serotonin receptors as well as for D2 receptors, and relative anatomical selectivity for limbic ...