Medicinal Chemistry
Glutamatergic and antiglutamatergic agents can also be prepared by targeting the non-NMDA receptors of glutamate. Trifluoro-AMPA ...
the brain. Strokes may be of two types: hemorrhagic (in which the artery actually ruptures or leaks) or ischemic (in which the a ...
approach using antiglutamatergic therapies. The rodent model of stroke does not fully capture these complexities in a realistic ...
calculations. Theoretical pharmacophore analyses using such calculations indicate that CRF-1 ligands should possess a hydrogen b ...
innervationand is controlled by a complex array of neurons, making it an ideal target for neuroactive agents.) 4.10.2 Neuropepti ...
Throughout the 1990s, molecular cloning enabled the identification of at least three novel galanin receptors: GALR1–3. These rec ...
because they are too small. It is not feasible to synthesize analogs of a substance like NO—it only has two atoms. Rather, it be ...
(by interacting with the heme moiety of soluble guanylyl cyclase to increase cGMP levels), precipitating a cascade of intracellu ...
4.11.4 Non-Neurologic Roles of NO Nitric oxide has many roles as a messenger outside of the nervous system. In organ systems, ra ...
In the lungs, NO affects not only blood vessels but also the bronchi and bronchioles as well. In newborns with defective gas exc ...
4.12 NEUROMODULATORS: TAURINE AND β-ALANINE Taurine (2-aminoethanesulfonic acid; 4.235) is an inhibitory neurochemical that prob ...
uptake” (via GAT proteins). β-Alanine binding sites have been identified throughout the hippocampus, other limbic structures, an ...
postjunctional membrane-potential modulators in ganglia. It appears that NE and ATP are cotransmitters in sympathetic synapses, ...
Purinergic antagonists include clonidine, a potent P 1 antagonist that is also an α 2 and H 2 agonist (see section 4.3.6), facil ...
A. D. Fryer, D. B. Jacoby (1998). Muscarinic receptors and control of airway smooth muscle. Am. J. Respir. Crit. Care Med. 158: ...
E. Costa, G. Racagni (Eds.) (1992). Typical and Atypical Antidepressants:Molecular Mechanisms. Advances in Biochemical Psychopha ...
P. Sneddon, D. P. Westfall, J. S. Fedan (1982). Cotransmitters in the motor nerves of the guinea-pig vas deferens: electrophysio ...
J. R. Fozard (1982). Highly potent irreversible inhibitors of aromatic L-amino acid decarboxylase. Trends Pharmacol.Sci. 3 : 429 ...
H. M. van Praag (1978). Amine hypothesis of affective disorders. In: L. L. Iversen, S. D. Iversen, S. H. Snyder (Eds.). Handbook ...
A. J. Robichaud, B. L. Largent (2000). Recent advances in selective serotonin receptor modulation. Ann. Rep. Med. Chem. 35: 11. ...
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