Medicinal Chemistry

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W. Hevers, H. Luddens (1998). The diversity of GABAAreceptors: pharmacological and electrophysiological properties of GABAAchann ...

Glycine and Glutamate B. Bettler, C. Mulle (1995). Neurotransmitter receptors: AMPA and Kainate. Neuropharmacology 34 : 123. H. ...

T. Pedrazzin, F. Pralong, E. Grouzmann (2003). Neuropeptide Y: the universal soldier. Cell. Mol. Life Sci. 60: 350–377. L. Prota ...

310 5 Messenger Targets for Drug Action II Hormones and their receptors 5.1 OVERVIEW OF RELEVANT ANATOMY AND PHYSIOLOGY OF HORMO ...

nervous system–endocrine system linkage. The thyroid gland, located in the neck, secretesthyroxineas its messenger hormone; by m ...

Hormones are ideal targets for rational drug design. Since hormones are precise chemical messengers influencing specific metabol ...

receptors. Within the target organs in which the steroids bind, the steroid molecules exert their influence directly on protein ...

complex.” Following optimal binding of the steroid to its receptor, the mature complex dissociates, releasing the chaperones and ...

These considerations apply to all cycloalkane derivatives, including steroids. However, the chair form of a ring is inherently m ...

(LH) and follicle-stimulating hormone(FSH) (the gonadotropins) act on the ovaries and testes. Gonadotropins induce the productio ...

dissolved with 1–2 years of treatment. Stone formation may recur after cessation of the therapy. Not surprisingly, surgical ther ...

In addition to high levels of serum cholesterol and cholesterol esters, a combination of other molecular factors appears to be n ...

In addition to treatment with the statins, hypercholesterolemia is sometimes treated with the use of nonabsorbable anion-exchang ...

also adsorb co-administered drugs such as digitoxin and diuretics, thereby decreasing their bioavailability. Another drug that i ...

Estrogens, which regulate ovulation and the development of the secondary female sex characteristics Progestins, or gestagens, w ...

excrete a variety of equine estrogens, including equilenin (5.25), a steroid containing the naphthalene ring system, and equilin ...

“thickness” of the molecule is important to its activity: the planes of the two phenyl groups must have a 60° torsion angle, and ...

5.8.3 Therapeutic Uses of Estrogens The most common use of estrogens is in birth control pills. Since estrogen is combined with ...

which is much higher than the normal rate. Also, antiestrogen use is associated with birth defects in 2–3% of live newborns. Ant ...