Science - USA (2021-12-03)

Peak levels of anti-spike and anti-RBD immuno- globulin G (IgG) were observed 1 week after the second vaccine dose and subsequen ...

Goelet al.,Science 374 , eabm0829 (2021) 3 December 2021 4of17 Spike+ IgG+ Spike+ IgM+ Spike+ IgA+ (^0) 0.50.75 (^1360) 0.50.75 ...

neutralization titers correlated with both anti- spike IgG and RBD-ACE2 binding inhibition (fig. S3, A to D). The neutralization ...

Goelet al.,Science 374 , eabm0829 (2021) 3 December 2021 6 of 17 B.1.1.7+ B.1.351+ B.1.617.2+ Infectio n Recovere d Naiv e WT RB ...

trimer, potentially allowing for increased recruitment and/or selection of specific clones that can bind conserved regions of RB ...

and four SARS-CoV-2–recovered individuals at 3 to 4 months postvaccination (Fig. 4A and fig. S5A). Consistent with our previous ...

Goelet al.,Science 374 , eabm0829 (2021) 3 December 2021 9 of 17 Gated on Non-Naive CD4+ T A Activation Markers 24 hours CD4+ T ...

these responses in SARS-CoV-2–recovered individuals. Antigen-specific T cells can further be clas- sified into different memory ...

in recall responses. Because we observed that memory B cell frequencies continue to in- crease in the months postvaccination, we ...

Finally, we evaluated the decay kinetics of SARS-CoV-2–specific recall responses. Boost- ing of spike- and RBD-specific memory B ...

Subjects were stratified on the basis of self- reporting and laboratory evidence of a prior SARS-CoV-2 infection. All subjects r ...

and mixed together after multimerization with 5 mM free D-biotin (Avidity LLC) to minimize potential cross-reactivity between pr ...

Core Facility at the University of Pennsylvania using an Illumina 2× 300-bp paired-end kit (Illumina MiSeq Reagent Kit v3, 600-c ...

witha= 0.05). The detection limit for sub- jectiwas calculated by taking the maximum value ofDMINi;jacross all time points for t ...

convalescent donors and vaccine recipients.Sci. Immunol. 6 , eabj1750 (2021). doi:10.1126/sciimmunol.abj1750 A. Tarkeet al., Co ...

Yes, I would like more information about joining the AAAS 1848 Society. PLEASE CONTACT ME AT: Name: Address: City: State: Zip co ...

RESEARCH ARTICLES ◥ MECHANICAL BONDS Active mechanisorption driven by pumping cassettes Liang Feng^1 †, Yunyan Qiu^1 †, Qing-Hui ...

steady state indefinitely, before being released on demand into the bulk by a process that involves the breaking of coordinative ...

gate (CG) at the other end with a ring-collecting chain located in the middle of a pseudo- dumbbell. An acid-base reaction (Fig. ...

The noncoordinating redox reagents co- baltocene (Cp 2 Co, reductant; Cp stands for cyclopentadienyl anion) and ferrocenium hexa ...