Science - USA (2021-12-03)

several hours released the mechanisorbed rings, MPCG13+and Zr-BTB, for subsequent use ( 53 ). After desorption, the solid was di ...

growing [n+1]rotaxanes (n= 1 to 5) aligned on the MOF surfaces, storing increasingly higher-energy structures as the number of r ...

Q. Liet al.,Science 325 , 855–859 (2009). K. Zhu, C. A. O’Keefe, V. N. Vukotic, R. W. Schurko, S. J. Loeb, Nat. Chem. 7 , 514–5 ...

was associated with 13.9 mg/dl lower LDL-C (P= 4.1 × 10–^19 , all single-variant regression used an additive model, andPvalues w ...

(n=826,beta=–29 mg/dl,P= 1.3 × 10–^5 ). We also found that the mean level of AST in^352 Ser homozygotes was twofold higher than ...

P= 5.2 × 10–^6 ,ttest] and higher AST [beta = 0.234 (1.7 U/L),P= 1.2 × 10–^7 ,ttest], but no association with HDL or ALT (P> ...

groups ( 21 ). As expected from B4GALT1’s role in processing N-linked carbohydrate, all samples had normal profiles for ApoCIII ...

decrease in body weight; 0.001 <P< 0.04 and 0.004 <P< 0.03 for heterozygotes and homozygotes, respectively; analysis ...

O. Staretz-Chachamet al.,Clin. Genet. 97 , 920– 926 (2020). C. Pérez-Cerdáet al.,J. Pediatr. 183 , 170–177.e1 (2017). O. Iourin ...

1228 3 DECEMBER 2021¥VOL 374 ISSUE 6572 science.orgSCIENCE Fig. 1. Cells deficient in O 2 reduction retain the capacity to input ...

input of electrons into the ETC, we monitored the activity of DHODH. DHODH oxidizes di- hydroorotate into orotate and deposits t ...

1230 3 DECEMBER 2021¥VOL 374 ISSUE 6572 science.orgSCIENCE Fig. 2. Upon inhibition of O 2 reduction, fumarate accepts electrons ...

SCIENCEscience.org 3 DECEMBER 2021¥VOL 374 ISSUE 6572 1231 Fig. 3. Fumarate reduction is required to maintain nucleotide biosynt ...

tracing of^13 C 515 N 2 -glutamine requires a ratio- metric analysis of labeled succinate to labeled fumarate to normalize for d ...

SCIENCEscience.org 3 DECEMBER 2021¥VOL 374 ISSUE 6572 1233 Fig. 4. Fumarate reduction supports mitochondrial functions in tissue ...

had a higher rate of succinate oxidation than fumarate reduction, whereas the opposite was the case in antimycin-treated mitocho ...

in theDYMito, which was restored to pretreat- ment levels with a similar timing as it takes for antimycin to increase fumarate r ...

driven by an increase in fumarate reduction, we calculated the ratio of the absolute con- centration of^13 C 3 -succinate to tha ...

K. K. Brown, J. B. Spinelli, J. M. Asara, A. Toker,Cancer Discov. 7 , 391–399 (2017). J. Rohlena, L.-F. Dong, S. J. Ralph, J. N ...

topological nature of the state by measur- ing the topological entanglement entropy. By simulating interferometry of toric code ...