Textbook of Personalized Medicine - Second Edition [2015]

547 6MWT. Several candidates designed to skip other exons and address additional mutation groups are currently in preclinical de ...

548 Personalizing New Therapies for CF However, new therapies to modulate defective CFTR, the basic defect underlying CF, have s ...

549 Hoffman EP, Brown RH, Kunkel LM. Dystrophin: the protein product on Duchenne muscular dystrophy locus. Cell. 1987;51:919–28. ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_17, 551 © Springer Science+Business Media New York 2 ...

552 Immunological tests have an important place in the future of personalized medi- cine. The role of immune system in personali ...

553 been carried out to defi ne therapeutic windows based on the blood levels of each immunosuppressant, and relating those conc ...

554 treatments. Several clinical studies have tested new therapies directly targeting B lymphocytes. Flow cytometry of circulati ...

555 examining their DNA for chemical tags – methyl groups – that could attach them- selves to genes and turn them on or off (Liu ...

556 Biomarkers for Personalizing Therapy of Rheumatoid Arthritis Vectra™ DA (Crescendo Bioscience), multi-biomarker blood test f ...

557 DIATSTAT™ Anti-cyclic Citrullinated Peptides in Rheumatoid Arthritis Effective disease management in RA requires early diagn ...

558 of treatment regimens may be benefi cial. A study using radioimmunoassays to measure levels of anti-infl iximab antibody and ...

559 suffer heart disease, diabetes, infections and cancer. These drugs are also toxic, and they can slowly poison the very kidne ...

560 moderate/severe acute cellular rejection at the time of testing. IMAGE study in 2010 showed the non-inferiority of clinical ...

561 Several novel immunosuppressive agents and new formulations, including siro- limus, mycophenolic acid (the active metabolite ...

562 transplant recipients. A sentinel signature has been characterized raising the possi- bility of application of blood leukocy ...

563 Patients with low ST2 values had lower mortality without relapse than patients with high ST2 values, regardless of the GVHD ...

564 Hronová K, Šíma M, Světlík S, et al. Pharmacogenetics and immunosuppressive drugs. Expert Rev Clin Pharmacol. 2014;7:821–35. ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_18, 565 © Springer Science+Business Media New York 2 ...

566 Efforts to prevent DM in the future will be tailored to high-risk individuals rather than populations and will be based on g ...

567 Biomarkers of IBD In 2012, Genisphere and the Lankenau Institute for Medical Research expanded their research collaboration ...