Science - USA (2022-01-07)
REVIEW SUMMARY ◥ CANCER Tertiary lymphoid structures in cancer Ton N. Schumacherand Daniela S. Thommen BACKGROUND:Tertiary lymph ...
REVIEW ◥ CANCER Tertiary lymphoid structures in cancer Ton N. Schumacher^1 and Daniela S. Thommen^2 Ectopic lymphoid aggregates ...
to contrast it to the formation of SLOs during embryogenesis. The seeding and organization of SLOs, specifically of lymph nodes ...
heterogeneity for which a reasonable amount of evidence does exist relates to the extent of TLS maturation. Three maturation sta ...
phenotypic characteristics of TFHcells in ex- perimental autoimmune encephalomyelitis models ( 55 ), suggesting that a reeducati ...
to their possible role as producers of opsoniz- ing tumor-specific antibodies, TLS-resident B cells may also suppress tumor-spec ...
specifically alter TLS properties in situ could offer a powerful approach to address such questions of causality. A number of re ...
on the type of chemotherapy used or on the concomitant treatment with steroids. One important factor to consider is that al- tho ...
30 , 2678–2683 (2012). doi:10.1200/JCO.2011.37.8539; pmid: 22711850 P. Savaset al., Single-cell profiling of breast cancer T ce ...
C. Gu-Trantienet al., CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer.JCI Insight ...
S. Shalapouret al., Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.Nature 521 , 94–98 (2015). ...
RESEARCH ARTICLE SUMMARY ◥ ORGANOIDS Tissue geometry drives deterministic organoid patterning N. Gjorevski†, M. Nikolaev†, T. E. ...
RESEARCH ARTICLE ◥ ORGANOIDS Tissue geometry drives deterministic organoid patterning N. Gjorevski^1 †‡, M. Nikolaev^1 †‡, T. E. ...
maintained in long-term cultures ( 13 ), which suggests that tissue shape directly influences patterning. To test this hypothesi ...
were preferentially localized to the same end- locations as the ISCs (Fig. 2, F and G), whereas the latter were on average exclu ...
therefore inactivation, was observed (Fig. 3, E and G). This geometry-dependent region- alization of YAP activity was again lost ...
YAP activity. In line with this model, abrogat- ing spatial gradients in YAP activity by uni- form induction [via treatment with ...
these features, along with the possibility of live imaging, to explore the process of intestinal shedding. Shedding is an import ...
and control that are major limitations of or- ganoids, undercutting their utility in basic and translational research. The contr ...
DMEM:F12 medium and stored in the incu- bator. Intestinal organoids were cultured in Matrigel following previously published pro ...
«
1
2
3
4
5
6
7
8
9
»
Free download pdf