Organic Chemistry of Drug Synthesis. Volume 7
product with piperidine under somewhat more forcing conditions with replaces the terminal chlorine on the ether-linked side chai ...
NH O Cl O O 190 + H^2 N F Br 191 Cl NH 2 O NH F Br 192 CDI Cl NH O N F O Br 193 Cl N O N F O Br BrCH 2 CO 2 C 2 H 5 2. NaOH CO ...
the azepinone carbonyl group with borohydride affords the vasopressin antagonisttolvaptan( 207 ).^29 NO 2 Cl CO 2 H SnCl 2 1 . ...
S. Evangelista,Curr. Opin. Inevest. Drugs 6 , 717 (2005). G.A.M. Giardina et al.,J. Med. Chem. 42 , 1053 (1999). D.B. Damon, R. ...
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CHAPTER 9 9 BICYCLIC FUSED HETEROCYCLES 1. COMPOUNDS WITH FIVE-MEMBERED RINGS FUSED TO SIX-MEMBERED RINGS A. Compounds with Two ...
N O NaH H 5 C 2 O 2 CCl 1 N C 6 H 4 Cl O H 5 C 2 O 2 C 2 H 2 S H 2 NH S O 3 NH S CH 3 CO 4 F Br + NC 6 Mg F O N S CH 3 CO O F ...
endogenous substances that includes not only ACE but a number of other enzymes involved in regulation of the cardiovascular func ...
serious limitations. The benzodiazepines that came along in the 1960s were better tolerated though these too had their drawbacks ...
lithiated on the pyrrole ring. Condensation of that species with the highly protected aminosugar ( 34 ) results in addition of t ...
amino group is then protected as itstert-butyl carbamate ( 42 ). Reaction of 42 with iodo sucinimide proceeds to form the 3-iodo ...
C. Compounds with Four Heteroatoms The A 1 adenosine receptors fulfill a largely inhibitory role. Research has thus recently foc ...
conditions. Thus, the A 1 adenosine receptors agonist selodenoson is obtained ( 59 ).^9 N N N N HO OH OO 54 N N N N HO 2 C OH C ...
the product from formation of an imine from each aldehyde ( 66 ). Replacing the ester with an amide by ester interchange with me ...
HO O O THP O O THPO 68 69 THP = tetrahydropyrranyl Selectride OH 70 CH 3 C 6 H 4 SO 2 Cl N N NH N NH 2 N N N NH 2 THPO N OTHP 71 ...
with ammonia to afford the product ( 82 ) from replacement of fluorine. Reaction of this intermediate with ammonia under more st ...
The concept of inhibiting cell growth by providing false substrates in fact well predates its application to antiviral agents. T ...
N N N N Cl Cl N N N N Cl Cl C 6 H 5 CO (^2) O O O O O O HO 95 CH 3 C 6 H 4 SO 3 Cl O O O O O TsO 96 KF O O O O O F H 2 SO 4 C 6 ...
nitrite in the presence of acid converts the amino group at the 4 position to the corresponding hydroxyl derivative. Saponificat ...
N N O NH 2 NH 2 116 O + OCH 3 OCH 3 HO 2 C 117 EDAC EDAC = 1-ethyl-3-(3-dimethylaminopropyl) carbodimide N N O NH 2 NH 118 O OCH ...
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