Organic Chemistry of Drug Synthesis. Volume 7
for agents that decrease platelet aggregability: Widely used clopidogrel, for example, blocks adenosine diphosphate receptors on ...
the amide carbonyl is converted to a thioamide with phosphorus pentoxide 64. Reaction of this last intermediate with hydrazine g ...
product 74 , which contains the secondary amine required for coupling with the other major fragment. Synthesis of the second het ...
is alkylated with 3-bromopropionitrile; the terminal cyano group is then reduced to the primary amine by means of Raney nickel ( ...
2. COMPOUNDS WITH FOUR FUSED RINGS The serious side effects associated with long-term use of dopamine anta- gonist antipsychotic ...
( 107 ) was interestingly first described in a 1979 patent.^12 Data on this agent using more recent pharmacological methods appa ...
by assuming initial displacement of terminal chlorine by the amine to give the transient intermediate 112. This amino group then ...
N N O O O HO HNO 3 H 2 SO 4 N N O O O HO O 2 N 114 115 The production by total synthesis of an analogue that incorporates an add ...
Sequential reduction of the ketone and dehydration of the resulting alcohol introduces a double bond. Hydrogenation then both re ...
Subject Index Boldnumerals refer to syntheses Abortion, non-surgical, 32 Acamprosate, 15 Acne, 37 Acolbifene, 163 Acyl-CoA: chol ...
Asenapine, 228 Asoprinosil, 32 Asthma, treatment, 29, 35, 90, 202 Atazanavir, 7 Atrasentan, 87 Atreluton, 90 Atrial natriuretic ...
Donepezil, 1 Dopamine D4 receptor, 166 Dopamine, 63, 75 Dopamine, partial agonist, 150, 159 Doramapimod, 74 DPP, in diabetes, 84 ...
Inhibitor (Continued) dihydrofolate reductase, 125 dopamine hydroxylase, 97 dopamine, re-uptake, 63 DPP, 83, 84 elastase, 54 end ...
Namindinil, 51 Nateglinide, 15 Naxifylline, 203 Nelarabine, 200 Neovascularixation, 34, 47, 140 Nepicastat, 97 Netoglitazone, 10 ...
Risperidone, metabolite, 209 Rivastigmine, 66 Rivoglitazone, 157 Roflumilast, 44 Rosuvastatin, 124 Rotigotine, 75 RU-486, 32 Rub ...
Viagra, 127 Vidagliptin, 84 Vinblastine, 11 Vincristine, 11 Virus, avian influenza, 25 Virus, cell-surface receptor, 107, 134 Vi ...
...
Cross Index of Biological Activity Alcoholism Treatment Acamprosate, 15 Aldose Reductase Inhibitors Lidorestat, 145 Zenarestat, ...
Antibacterial(Continued) Sitafloxacin, 174 Antidepressant Citalopram, 140 Elzasonan, 136 Flibanserin, 158 Igmesine, 64 Lubazodon ...
Taltobulin, 11 Tamibarotene, 76 Tandutinib, 183 Tanomastat, 47 Tezacitabine, 131 Tipifarnib, 172 Topixantrone, 227 Troxacitabine ...
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