Science - USA (2022-02-04)

REVIEW ◥ CHEMICAL POLLUTION Per- and polyfluoroalkyl substances in the environment Marina G. Evich^1 †, Mary J. B. Davis^1 †, Ja ...

Major PFAS groups from direct fluorination include those hydrofluorocarbons, hydrofluoro- ethers, hydrochlorofluoroolefins, and ...

Evichet al.,Science 375 , eabg9065 (2022) 4 February 2022 3 of 14 Oligomerization Direct fluorination Non-PFAS base chemicals HF ...

Three other major PFAS groups formed from oligomerization are fluorotelomers, per- fluoroalkyl(ether) carboxylic and sulfonic ac ...

In addition to accounting for environmental conditions ( 67 ), another complicating factor is that contaminants commonly exist a ...

although transformation kinetics of PFAS mix- tures has not been reported. Furthermore, these complex mixtures could have down- ...

suggest that chemical properties of PFAS also exert a strong influence over plant uptake. Re- ports of plant uptake of emerging ...

summary characterizations such as Total Or- ganic Fluorine and Total Oxidizable Precursor assays as proxies for more informative ...

bond, complete mineralization is difficult, with fluorinated products of incomplete de- struction remaining a concern ( 142 , 14 ...

PFAS-affected drinking water often is the primary route of human exposure ( 146 ), and treatment techniques for aqueous media ar ...

most PFAS do not naturally degrade to non- fluorinated chemical species, these long-term sinks are time-delayed sources. For exa ...

of alkyl sulfonyl fluorides.Environ. Sci. Technol. 47 , 382– 389 (2013). doi:10.1021/es303152m; pmid: 23205559 A. A. Rand, S. A ...

degradation in an anaerobic microbial community. Environ. Sci. Process. Impacts 21 , 1915–1925 (2019). doi:10.1039/C9EM00241C; p ...

polyfluoroalkyl substances across aquatic species. Environ. Toxicol. Chem. 40 , 1530–1543 (2021). doi:10.1002/etc.5010; pmid: 33 ...

RESEARCH ARTICLE SUMMARY ◥ IMMUNOLOGY CRISPR activation and interference screens decode stimulation responses in primary human T ...

RESEARCH ARTICLE ◥ IMMUNOLOGY CRISPR activation and interference screens decode stimulation responses in primary human T cells R ...

they could miss necessary components that wouldonlybeidentifiedthroughloss-of- function studies. We therefore performed recip- r ...

Schmidtet al.,Science 375 , eabj4008 (2022) 4 February 2022 3 of 12 TAF4TT PTPRC CD3G VVAVAV1IL2 ZAP70 CD3D CD3E LCP2 CD2CD28 CD ...

overlapped across all CRISPRa screens, likely representing core regulators of type 1 cytokine production in response to stimulat ...

Schmidtet al.,Science 375 , eabj4008 (2022) 4 February 2022 5 of 12 APOBEC3C APOBEC3D FOXQ1OO IFNG IL2 IL2RB LAT2AA MAP4K1 OTUD7 ...