Science - USA (2022-02-25)

IIc ( 13 ) and was used to assist crystallization. Furthermore, we used surface plasmon reso- nance (SPR) to evaluate the bindin ...

from neutralization mediated by a panel of NTD mAbs ( 7 , 9 ). The RBD is the main target of plasma- neutralizing activity in co ...

(Fig. 4A and table S2). The N501Y mutation alone enhances ACE2 binding to the RBD by a factor of 6 relative to the Wuhan-Hu-1 RB ...

by SARS-CoV-2 Omicron and underscores the SARS-CoV-2 S mutational plasticity as well as the importance of targeting con- served ...

ORGANIC CHEMISTRY Deracemization through photochemicalE/Z isomerization of enamines Mouxin Huang^1 †, Long Zhang1,2†, Tianrun Pa ...

undergo reduction and condensation while main- taining enantiopurity (Fig. 2B). In our deracemization process, the photo- chemic ...

SCIENCEscience.org 25 FEBRUARY 2022¥VOL 375 ISSUE 6583 871 Fig. 2. Substrate scope and synthetic application.(A) Substrate scope ...

formedE-enamine, equilibrating at about 50% conversion (Fig. 3D, a), whereas (R)-2apref- erentially gaveZ-enamine, which was equ ...

matched enantiomer and accumulation of the mismatched enantiomer are sustained to facil- itate effective deracemization. In this ...

E. Arceo, I. D. Jurberg, A. Alvarez-Fernández, P. Melchiorre, Nat. Chem. 5 , 750–756 (2013). M. Silvi, E. Arceo, I. D. Jurberg, ...

duration of the outburst. The orbital incli- nation has been constrained to the range 66°<iorb<81° by the lack of x-ray ec ...

orbital angular momentum or the black hole spin is instead directed to the north, the black hole rotation is then retrograde, re ...

CANCER IMMUNOLOGY Molecular signatures of antitumor neoantigen- reactive T cells from metastatic human cancers Frank J. Lowery^1 ...

C0, represented the most-differentiated TILs within these cell populations (fig. S1E). By integrating 23,712 TCR clonotypes with ...

C7 TILEMstates but were largely absent in C1, C6, and C9 clusters containing tumor- expanded clones (Fig. 1F). By contrast, TCR ...

to prospectively predict antitumor, neoantigen- specific TCRs purely on the basis of TIL tran- scriptomic states. We first teste ...

AUCs > 0.9; table S10, tab 4). These data to- gether suggest that the TIL dysfunctional pro- gram identified here is not limi ...

similar to those of exhausted CD8 cells ob- served in basal and squamous cell carcinoma (Yost.CD8.Exhausted, Pearson’sr= 0.766) ...

the ability of given signatures to call CD4+ NeoTCRs, CD8+NeoTCRs, and public viral TCRs from the archival specimens (training s ...

NIH HPC Biowulf cluster (http://hpc.nih.gov). We also thank NIDAP for providing additional computational support and the CCR Gen ...