Biology of Disease
replace diseased or nonfunctional tissue is now well established. However, it is little more than 50 years since the first succe ...
Figure 6.1Some blood products: (A) plasma (B) erythrocytes and (C) platelets. Courtesy of the Manchester Blood Transfusion Servi ...
BOX 6.1 The flow cytometer The flow cytometer (Figure 6.3) is an instrument that can analyze several properties of cells simulta ...
to forward and side scatter, cells can be stained with fluorescent antibodies to proteins that are characteristic of a cell popu ...
X]VeiZg+/ TRANSFUSION AND TRANSPLANTATION &(' W^dad\nd[Y^hZVhZ ISBT Number Name Symbol 001 ABO ABO 002 MNS MNS 003 P P 00 ...
The Antigens of the ABO System The antigens that determine ABO blood groups are oligosaccharide constit- uents of cell surface g ...
Approximately 75% of Caucasians attach A, B and H antigens (depending on their blood group) to soluble proteins and secrete them ...
recipient bind to the donated erythrocytes and activate complement. This results in the simultaneous lysis of billions of erythr ...
individuals who are RhD negative are those with the genotype dce/dce (or rr using the Fisher code) and these constitute 15% of C ...
spontaneous abortion. A longer term child may be stillborn. The considerably enlarged spleen and liver in a child born alive wit ...
6.6 Other Blood Group Systems The Lewis blood group system (ISBT 007, symbol Le) is related the Lewis antigens Lea and Leb prese ...
only 9% of blacks, while the Jk(a–b–) phenotype is rare in both populations. Antibodies to Jka and Jkb belong to the IgM or the ...
6.8 Role of Complement in Transfusion Reactions In Chapter 4, the ‘beneficial’ role of complement in eliminating immuno- gens wa ...
samples of serum by hemolysis in vitro using the complement activity in the serum or they may be detected by examining the surfa ...
fall. To prevent either occurrence, the recipient should be screened before the transfusion for the presence of anti-erythrocyte ...
the increasing use of leukodepleted blood, in which the leukocytes have been removed prior to transfusion, prevents the immuniza ...
Category Examples Recent history of clinical intervention had a minor operation within the last month had a major operation with ...
6.11 Transplantation of Solid Tissues and Organs The transplantation of solid tissues from one individual to another for thera- ...
owing to the increased genetic disparity between the donor and the recipi- ent. Other more common examples of xenogeneic grafts ...
Sometimes rejection may take place within hours or minutes of transplanta- tion, once the tissue has become revascularized. This ...
«
4
5
6
7
8
9
10
11
12
13
»
Free download pdf