Cell - 8 September 2016
Figure S4. MS Analysis of the Lipids Extracted from F Pili, Related toFigure 4 (A) Negative ion mode survey scan (600–780 m/z) o ...
Figure S5. Details of pED208 TraA-phospholipid Interactions, Related toFigure 5 (A) Interaction diagram between one phospholipid ...
Figure S6. Details of TraA-TraA Interactions, Related toFigure 6 (A) Same asFigure 6A, repeated here for clarity. (B) Interactio ...
Article Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice Graphical Abstract Highlig ...
Article Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice Amelia Escolano,1,6Jon M. ...
that produces a persistent immune response to a highly variable infection (Bhiman et al., 2015; Doria-Rose et al., 2014; Kwong e ...
H330A (10MUT knockout [KO]) (Figures 1A and 1B). Despite the specificity of the response, immunization with 10MUT did not elicit ...
10MUT and native-like antigens and showed varying affinities (1–10 nM) for the mature PGT121 antibody (Figures 1C and 1D) (Steic ...
lower levels of SHM at both the nucleotide and amino acid levels in GLHL121 and MutHGLL121 B cells than the sequential protocol ...
acid mutations and the number of amino acid substitutions that were similar to those found in the bNAbs (r^2 = 0.796,Figures 6A ...
retained (R103 and Y105, which make contacts with N332 glycan and the GDIR motif, respectively). Similarly, the IGK in the neutr ...
did not elicit neutralizing responses in mice that carry the germ- line precursors of CD4bs antibodies (Dosenovic et al., 2015; ...
Figure 6. Monoclonal Antibody-Neutralizing Activity (A) 3D plot showing neutralization activity (color coded), total number of a ...
proof of concept for the idea that sequential immunization can elicit bNAbs. The sequential boosting protocols that succeeded to ...
Figure7. AlignmentoftheMonoclonalIGHandIGKtotheInferredGermlineandMatureMutatedPGT121,PGT122,PGT123,and10-1074bNAbs (A) Alignmen ...
NIH Grants AI100148 and AI109632 (M.C.N.); the International AIDS Vaccine Initiative Neutralizing Antibody Consortium and Center ...
therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature 492 , 118–122. Klein, F., Diskin, R., Sche ...
hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS Pathog. 9 , e10037 ...
STAR+METHODS KEY RESOURCES TABLE REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Peroxidase-conjugated AffiniPure Goat Anti-mou ...
CONTACT FOR REAGENT AND RESOURCE SHARING Further information and requests for reagents may be directed to the corresponding auth ...
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