Science - USA (2022-04-15)
B. S. Ripley, J. Cunniff, C. P. Osborne, Photosynthetic acclimation and resource use by the C 3 and C 4 subspecies ofAlloterops ...
ACKNOWLEDGMENTS We are grateful to A. Carew for graphic design assistance and to J. Penuelas, R. Sabo, M. Engardt, and D. Simpso ...
Publishyourresearch intheSciencefamilyofjournals TheSciencefamilyofjournals(Science, Science Advances,ScienceImmunology, Science ...
RESEARCH ARTICLE SUMMARY ◥ LIPIDOMICS Sphingolipids control dermal fibroblast heterogeneity Laura Capolupo, Irina Khven, Alex R. ...
RESEARCH ARTICLE ◥ LIPIDOMICS Sphingolipids control dermal fibroblast heterogeneity Laura Capolupo^1 , Irina Khven^2 , Alex R. L ...
decreasing CV. Sphingolipids populated the top CV ranking positions, confirming that the sphingolipid pathway (fig. S1F) is subj ...
activities responsible for Cer processing, rather than those producing different Cer backbones, are variable at a cell-to-cell l ...
B4GALT5encoding lactosylceramide synthase (LCS) reduced toxin binding (fig. S2, B and C) without inducing significant toxicity ( ...
by mass imaging (fig. S2, E and F). We then analyzed dHFs derived from four unrelated healthy individuals that displayed an anal ...
Capolupoet al.,Science 376 , eabh1623 (2022) 15 April 2022 6 of 12 AB Cycle G1/S Cycle G1 Cycle G2 Cycle M Cycle M/G1 Middle Bas ...
compared with matched dHFs (Fig. 5, G and H). These data indicate that dHF lipotypes are reflected by fibroblast subtypes popula ...
mechanisms. Therefore, lipotypes are asso- ciated with cell states, yet cell states are not endowed with transcriptional program ...
andCCL2were up-regulated in Gb4S-OE cells and down-regulated in GM3S-OE cells (fig. S8G). Moreover, when reticular and papillary ...
dHFs and bulk RNA-seq on five cell populations isolated by FACS according to their lipid com- position were performed. Skin tiss ...
R. R. Driskell, F. M. Watt, Understanding fibroblast heterogeneity in the skin.Trends Cell Biol. 25 , 92–99 (2015). doi:10.1016 ...
L.C. developed the idea, conducted the experiments, and wrote the manuscript. I.K. participated in the development of the idea, ...
RESEARCH ARTICLE SUMMARY ◥ NEUROIMMUNOLOGY Bacterial sensing via neuronal Nod2 regulates appetite and body temperature Ilana Gab ...
RESEARCH ARTICLE ◥ NEUROIMMUNOLOGY Bacterial sensing via neuronal Nod2 regulates appetite and body temperature Ilana Gabanyi1,2, ...
Gabanyiet al.,Science 376 , eabj3986 (2022) 15 April 2022 2 of 12 Thalamus Hypothalamus AB NeuN Iba1 Overlay C D Nod2 GFP Nod2 G ...
period of several months,VgatDNod2females gained more weight than didNod2floxand Vgatcrecontrols (Fig. 2A). Weight differences b ...
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