Science - USA (2022-04-15)
To better interpret changes in sensory stim- ulus representation after learning, we first ex- amined the stability of somatic CS ...
We then performed a 3-day differential au- ditory FC paradigm in a separate group of mice while recording somatic and dendritic ...
Whereas the overall average somatic CS- response magnitude remained similar after FC(Fig.4,CtoF),neuronscouldbesub- divided into ...
plasticity types contribute to the new CS repre- sentation in the amygdala after conditioning. Associative FC induces differenti ...
( 28 – 30 ). SST+ interneurons, in particular, pre- dominantly contact PN dendrites and provide input-specific inhibition to PNs ...
CS-US pairings. By contrast, in unpaired con- ditioned mice exposed to equal CSs and USs, but in a temporally unpaired manner, C ...
In support of the latter, suppressing the ac- tivity of soma-targeting PV+ interneurons re- duced the proportion of CSdown neuro ...
pad (FHC). A 3D imaging volume, centered on the imaging plane previously used for func- tional imaging, was acquired with a 2mm ...
signal. Then, images were corrected for rigid and for non-rigid motion using Normcorre ( 55 ). Registration across imaging sessi ...
bottom tip of the GRIN lens was located out- side the LA; (ii) brain motion was too great to be corrected post-hoc; (3) GCaMP6 l ...
P. Poirazi, A. Papoutsi, Illuminating dendritic function with computational models.Nat. Rev. Neurosci. 21 , 303– 321 (2020). do ...
Yes, I would like more information about joining the AAAS 1848 Society. PLEASE CONTACT ME AT: Name: Address: City: State: Zip co ...
RESEARCH ARTICLE ◥ NEUROSCIENCE Dynamic compartmental computations in tuft dendrites of layer 5 neurons during motor behavior Ya ...
Fig. 2A). This raised the possibility of mul- tiple subpopulations of calcium events. Indeed, visual inspection suggested four q ...
four calcium event clusters and for all events (Fig. 1, I and J). We quantified the anatomical-functional correlations using thr ...
measured the relationship between the pair- wise Pearson activity correlations to the distance between ROIs with a linear regres ...
clusters resulted in higher Mantel statistics (Fig. 2I) and a stronger dependence between pairwise Pearson correlations and tuft ...
portions of the tree were more strongly cor- related than others. Similar results were ob- tained when event clustering was base ...
of peak calcium events and the peak calcium amplitudes of the clusters were comparable in type 1 and 2 PTNs (fig. S3, C and D). ...
chance 0.52 for both clusters). This finding further strengthens the anatomical subdivision based on independent physiological p ...
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