Science - USA (2022-04-15)
than in control mice (Fig. 2H and fig. S4F). Moreover, femaleVgatDNod2mice showed de- layed temperature drops in response to fas ...
sphingosine-1-phosphate released under cellu- lar stress conditions ( 31 ). The lack of Nod2 in inhibitory neurons had particula ...
intestinal and blood-brain barrier permeability, as well as microbiota composition—are also likely to play a role ( 32 , 37 – 39 ...
Gabanyiet al.,Science 376 , eabj3986 (2022) 15 April 2022 7 of 12 GH DMH ARC ROSAYFP I ** ** K CRE virusNod2flox CRE vir ...
decrease (as observed in pre-menopausal and menopausal states), this control of food intake would be attenuated and MDP’s ano- r ...
were gavaged with 60,000 cpm of^14 C-GlcNAc- labeled PG. Control mice were gavaged with the equivalent dilution of nonlabeled PG ...
Roche). For insulin measurements, samples were immediately placed on ice and centri- fuged at 14,000gfor 10 min at 4°C as soon a ...
Slices were visualized using a 40× water im- mersion objective (Zeiss Achroplan 440090; NA 0.75; no aberration correction; worki ...
R. D. Lisk, R. A. Pretlow 3rd, S. M. Friedman, Hormonal stimulation necessary for elicitation of maternal nest-building in the ...
RESEARCH ARTICLE SUMMARY ◥ SIGNAL TRANSDUCTION Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of ...
RESEARCH ARTICLE ◥ SIGNAL TRANSDUCTION Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1 ...
diet [the fructose, palmitate, and cholesterol (FPC) diet] (Fig. 1H). Phosphorylation of S6 was unchanged in mice fasted overnig ...
FLCN binds to and inhibits or activates adenosine monophosphate–activated protein kinase (AMPK) in various cell types ( 24 – 26 ...
Loss of FLCN in the liver suppresses de novo lipogenesis We had expected thatFlcndeletion would promote lysosomal and mitochondr ...
To measure DNL directly, we force-fed mice^13 C-fructose, a rich source of carbons for de novo lipogenesis in the liver, and qua ...
Gosiset al.,Science 376 , eabf8271 (2022) 15 April 2022 6 of 12 ControlLiFKO DKO 0 10 20 30 40 Body weight (g) Column min Column ...
of DNL was also evident in LiFKO mice fed normal chow (fig. S7B). Together, these data demonstrate that the FLCN:mTORC1:TFE3 axi ...
markers of fibrosis (Fig. 6, D and E), and suppressed steatosis and fibrosis measured through blinded histological evaluation (f ...
Gosiset al.,Science 376 , eabf8271 (2022) 15 April 2022 9 of 12 Relative expression Control Col1a1 mRNA LiFKOControlLiFKODKO Rel ...
A therapy intended to treat NASH and NAFLD would benefit from modifying es- tablished disease, in addition to preventing it. We ...
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