Stem Cell Processing (Stem Cells in Clinical Applications)

90 Recently, direct transdifferentiation from somatic cells to cardiomyocytes has been introduced as a safety protocol with a lo ...

91 endoderm differentiation from iPSCs can be promoted by using activin A or a combination of activin A with hepatocyte growth f ...

92 pluripotent factors, culture systems without animal cells or contamination, and iPSC production according to GMP standards. T ...

93 Chabot S, Orio J, Schmeer M, Schleef M, Golzio M, Teissie J (2013) Minicircle DNA electrotrans- fer for effi cient tissue-tar ...

94 Fusaki N, Ban H, Nishiyama A, Saeki K, Hasegawa M (2009) Effi cient induction of transgene-free human pluripotent stem cells ...

95 Jung DW, Kim WH, Williams DR (2014) Reprogram or reboot: small molecule approaches for the production of induced pluripotent ...

96 Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S (2008) Generat ...

97 Sinnecker D, Laugwitz K-L, Moretti A (2014) Induced pluripotent stem cell-derived cardiomyo- cytes for drug development and t ...

98 Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A et al (2010) Highly effi cient r ...

© Springer International Publishing Switzerland 2016 99 P.V. Pham (ed.), Stem Cell Processing, Stem Cells in Clinical Applicatio ...

100 potential of these adult MSCs. Their presence was fi rst reported by the works of Friedenstein and colleagues in which strom ...

101 infections (Ho et al. 2005 ). Ageing is also seen as a refl ection of the cumulative senescence of an organism’s component c ...

102 higher for MSCs from older patients throughout passages 1–4. This is also supported by Zhou et al. ( 2008 ) and Mareschi et ...

103 in Cba1/Runx2 (osteoblast marker) but no signifi cant relationship between age and SOX9 (adipocyte marker). Similarly with o ...

104 5.6 Conclusion Although there are no consistent results as to whether MSCs are affected by ageing, of those studies that did ...

105 Chen FH, Tuan RS (2008) Mesenchymal stem cells in arthritic diseases. Arthritis Research Ther 10:223 Clark WR (1999) A means ...

106 Muraglia A, Cancedda R, Quarto R (2000) Clonal mesenchymal progenitors from human bone marrow differentiate in vitro accordi ...

© Springer International Publishing Switzerland 2016 107 P.V. Pham (ed.), Stem Cell Processing, Stem Cells in Clinical Applicati ...

108 natural killer cells, dendritic cells, and T regulatory cells (Cardoso et al. 2012 ; Melief et al. 2013 ; Saeidi et al. 2013 ...

109 Recent studies have shown that allogeneic MSCs can perform better immunomodulation than autologous MSCs. These results trigg ...