Vertebrate Development Maternal to Zygotic Control (Advances in Experimental Medicine and Biology)

92 distinct subfamilies B/PPP2R2, B ́/PPP2R5, B ́ ́/PPP2R3 and B ́ ́ ́/Striatins. Alternative splicing of some of the mRNAs give ...

93 its counteracting phosphatase? The answer to this question started to emerge when the precise role of an AGC-type kinase call ...

94 3.5.1.2 The AGC-Type Kinase Greatwall (Gwl) Gwl belongs to the family of AGC-type kinases and shares many functional key resi ...

95 (Fig. 3.5) (Gharbi-Ayachi et al. 2010 ; Mochida et al. 2010 ). Initially, Arpp19 was identified as a cAMP-dependent neuronal ...

96 has not been fully addressed (Mochida 2014 ; Okumura et al. 2014 ). In contrast, studies in immature Xenopus laevis oocytes r ...

97 3.5.2.1 The Link Between PP2A-B ́56 and the APC/C Not surprisingly, the cell cycle regulatory machinery harnesses the interpl ...

98 3.6 Type 1 Protein Phosphatase (PP1) The Ser/Thr-phosphatase PP1 is a ubiquitous and highly conserved eukaryotic pro- tein th ...

99 3.6.2 PIPs Regulating PP1 Activity Some PIPs do not confer substrate selectivity, but act as inhibitors of the PP1 cata- lyti ...

100 Cdk1-stimulating and mitosis- promoting effect. Intriguingly, Xenopus egg extract studies revealed that PP1 is crucial for t ...

101 stockpiled into the giant oocyte (Akkers et al. 2009 ; Hontelez et al. 2015 ; Thompson et al. 1998 ). The time when active t ...

102 M-phase in mice, a characteristic which might account for the prolonged M-phase (Kubiak and Ciemerych 2001 ). In Xenopus, th ...

103 only by their extended duration but also by their asynchrony resulting in stages with uneven number of cells as compared to ...

104 cyclin- B mRNA by deadenylation, and studies in cycling Xenopus egg extract iden- tified maskin as an important regulator in ...

105 ES cells are characterised by high Cdk2 activity and elevated levels of both cyclins A and E throughout the cell cycle (Fuji ...

106 proteasomal destruction. Most likely, further studies will identify additional cell cycle regulators that are regulated in a ...

107 Artus J, Cohen-Tannoudji M (2008) Cell cycle regulation during early mouse embryogenesis. Mol Cell Endocrinol 282(1–2):78–86 ...

108 Dohadwala M, da Cruz e Silva EF, Hall FL, Williams RT, Carbonaro-Hall DA, Nairn AC, Greengard P, Berndt N (1994) Phosphoryla ...

109 Groisman I, Jung MY, Sarkissian M, Cao Q, Richter JD (2002) Translational control of the embry- onic cell cycle. Cell 109(4) ...

110 targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest. Mol Biol Cell 20(8):2186–2195. doi:10.1091/mbc ...

111 JC, Joensuu H, Westermarck J (2013) Senescence sensitivity of breast cancer cells is defined by positive feedback loop betwe ...