Infectious Agents Associated Cancers Epidemiology and Molecular Biology
255 pathogen and microenvironment based on potential therapeutic targets for the treat- ment of pathogen-associated cancer (Fig. ...
256 16.2.1 Deregulation of HIF-Dependent Hypoxic Signaling HIF-1, which consists of a constitutively expressed β-subunit and an ...
257 HIF/VHL pathway. For instance, both KSHV-encoded LANA and EBV-encoded LMP-1 have been demonstrated to induce the proteasome- ...
258 1 (4E-BP1) and the p70 ribosomal S6 kinase 1(S6K1) [ 34 ]. These two are critical effectors of the downstream of mTOR signal ...
259 activate p53 signaling through the enhancement of p53 stability and DNA-binding activity [ 48 ], which is tightly modulated ...
260 16.4.1 IL-6 Interleukin 6 (IL-6), secreted by a variety of host cells such as T cells, macrophages, fibroblasts, and maligna ...
261 downregulating MHCII antigen on monocytes and ultimately maintains EBV latent infection [ 84 , 85 ]. On the other hand, huma ...
262 KSHV, HTLV-1 Tax protein also induces production of IL-13, which is capable of promoting cell proliferation and anti-apoptos ...
263 16.4.5 CCL20 CCL20 is a member of CC chemokine subfamily and acts as a potent chemotaxin of immature dendritic cells, B lymp ...
264 adaptive signaling pathway. Thus, a dynamic and comprehensive perspective in understanding oncogenesis mechanism induced by ...
265 Wouters BG, Koritzinsky M (2008) Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cance ...
266 Kallio PJ, Okamoto K, O’Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L (1998) Signal transduction in hypoxic cells: i ...
267 aggresome formation and autophagy in cultured cardiac myocytes. Biochim Biophys Acta 6:509–518 Clanton TL (1985) Hypoxia-in ...
268 Jones KD, Aoki Y, Chang Y, Moore PS, Yarchoan R, Tosato G (1999) Involvement of inter- leukin- 10 (IL-10) and viral IL-6 in ...
269 Vockerodt M, Haier B, Buttgereit P, Tesch H, Kube D (2001) The Epstein-Barr virus latent membrane protein 1 induces interle ...
270 Wang C, Wei F, Cai Q (2016) Deregulation of IL-4/IL-13-induced STAT6 signaling in viral oncogenesis. Oncol Commun 1:e1131 L ...
271 Schutyser E, Struyf S, Van Damme J (2003) The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev 14:409–4 ...
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