Infectious Agents Associated Cancers Epidemiology and Molecular Biology
90 Goetze K, Walenta S, Ksiazkiewicz M, Kunz-Schughart LA, Mueller-Klieser W (2011) Lactate enhances motility of tumor cells an ...
© Springer Nature Singapore Pte Ltd. 2017 91 Q. Cai et al. (eds.), Infectious Agents Associated Cancers: Epidemiology and Molecu ...
92 or nodular lesions located in the lower extremity. In his clinical report, this sarcoma was first observed on the feet of fiv ...
93 7.1.2 Virion Structure As a typical herpesviral particle, KSHV consists of three major morphologically distinct parts: a high ...
94 represent different intermediates rather than a structurally homogenous group dur- ing the process of KSHV capsid assembly an ...
95 7.2 Epidemiology of KSHV 7.2.1 Prevalence and Genetic Diversity The prevalence of KSHV infection varies globally. The infecti ...
96 The genetic diversity can only be found among different individuals, which means the viral sequences are stable in a given in ...
97 transmission route for KSHV [ 62 ]. Studies in the AIDS-KS population showed that KSHV is consistently detected in patients’ ...
98 extremities, face, and genitalia and are typically multifocal, with the appearance of papules, patches, plaques, or nodules. ...
99 7.3 KSHV Life Cycle KSHV can successfully infect multiple cells including endothelial cells, B cells, monocytes, epithelial c ...
100 lular entry receptors for KSHV. Integrins are entry receptors utilized by KSHV in adherent cells such as endothelial cells, ...
101 The endosomal sorting complexes required for transport (ESCRT) proteins, including ESCRT-0, -I, -II, and -III, function in a ...
102 polymerase, and the replicated genomes are evenly distributed to the daughter cells. Latency is the default pathway of KSHV ...
103 episome from generation to generation [ 105 , 106 ]. The C-terminal DNA-binding domain of LANA interacts with the host TR se ...
104 MAP kinase-associated protein kinase 2 (MK2) and the upstream kinase, p38 MAP kinase [ 124 ]. miRNAs are 21–23 nucleotide lo ...
105 The RTA protein (691 amino acids and 110 kDa) has an N-terminal DNA-binding domain and a C-terminal activation domain that c ...
106 7.5 KSHV-Related Pathogenesis 7.5.1 An Overview of KSHV-Related Pathogenesis In established KS lesions, spindle cells accoun ...
107 KSHV infection induces spindle cell morphology in endothelial cells, as evi- denced by extensive in vitro data and in vivo o ...
108 NF-κB pathway, and upregulated EZH2 leads to the induction of Ephrin-B2, a well- known proangiogenic factor [ 179 ]. In addi ...
109 7.5.3 KSHV-Induced Immune Escape and Regulation During KSHV infection, the host immune system recognizes various pathogen- a ...
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