Infectious Agents Associated Cancers Epidemiology and Molecular Biology
50 4.9 Conclusions and Future Perspectives Accumulating evidence demonstrates a role for MCPyV in the development of MCC, making ...
51 Chang Y, Moore PS (2012) Merkel cell carcinoma: a virus-induced human cancer. Annu Rev Pathol 7:123–144 Heath M, Jaimes N, L ...
52 Neumann F, Borchert S, Schmidt C, Reimer R, Hohenberg H, Fischer N, Grundhoff A (2011) Replication, gene expression and part ...
53 Neu U, Hengel H, Blaum BS, Schowalter RM, Macejak D, Gilbert M, Wakarchuk WW, Imamura A, Ando H, Kiso M, Arnberg N, Garcea R ...
54 Vaigot P, Pisani A, Darmon YM, Ortonne JP (1987) The majority of epidermal Merkel cells are non-proliferative: a quantitativ ...
55 Zeng Q, Gomez BP, Viscidi RP, Peng S, He L, Ma B, Wu TC, Hung CF (2012) Development of a DNA vaccine targeting Merkel cell p ...
56 Murakami M, Imajoh M, Ikawa T, Nakajima H, Kamioka M, Nemoto Y, Ujihara T, Uchiyama J, Matsuzaki S, Sano S, Daibata M (2011) ...
© Springer Nature Singapore Pte Ltd. 2017 57 Q. Cai et al. (eds.), Infectious Agents Associated Cancers: Epidemiology and Molecu ...
58 population and sustains lifelong asymptomatic infection. Its ability to induce oncogenesis is likely due to suppression of th ...
59 5.2.2 Diffuse Large B-Cell Lymphoma (DLBCL) Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lym- phoma ( ...
60 germinal center. They require the necessary signals to escape apoptosis as a result of the lack of functional BCRs [ 36 ]. Th ...
61 5.3.1 EBV-Associated Transcription Regulatory Network One hallmark of cancer is the dysregulation of gene expression [ 47 ]. ...
62 expression [ 61 ]. Additionally, abundant enhancers (eRNAs) are also transcribed from ESEs and are regulated by the activity ...
63 transcription factors to manipulate the microenvironment during latent infection, suggesting the importance of EBV-expressed ...
64 Fig. 5.1 EBV latent antigen-associated cellular signaling pathways from the current high- throughput sequencing data during E ...
65 possibility of lymphomagenesis when the constitutive regions release the viral genome which leads to loss of normal DNA or ch ...
66 Rag2−/−Il2rg−/− mice and induce specific T-cell response [ 88 ]. A mouse model for EBV infection was established by transplan ...
67 diagnosed will develop relapsed or refractory disease after being treated for DLBCL [ 97 , 98 ]. Treatment of these patients ...
68 to be done to identify the link, if any, of DTX3L via CRCX4 with DLBCL. However, a therapy involving this control mechanism s ...
69 References Ceribelli M, Kelly PN, Shaffer AL, Wright GW, Xiao W et al (2014) Blockade of oncogenic IkappaB kinase activity i ...
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