Multiphase Bioreactor Design

Figure 12.8 shows how the liquid-liquid-solid three-phase fluidised bed is divided in stirred tanks to represent flow characteri ...

Medium-Phase Mass Balances substrate product Organic-Solvent-Phase Mass Balances Within this model two different kinds of parame ...

Calculations Before we compare a three-phase fluidised-bed bioreactor with its two-phase analogue, we will first show some typic ...

surface tension between water and dodecane 0.040 N/m diameter gel bead 2.76 mm diffusion coefficient substrate 10 –9 m/s diffusi ...

Figure 12.9 Profile of substrate (A) and product (B) concentration in a gel bead particle. Uc=1.29 cm/s Ud=0.91 cm/s, εs=0.32, ε ...

● At the point in time where substrate is not longer converted, there is equilibrium for the product concentration between the m ...

In our comparison we did the simulations for batch operations: Substrate is circulated until a certain amount of substrate is co ...

Uc=1.29 cm/s, Ud=0.91 cm/s, εs=0.32, εo=0.0925; Xvmax=0.01 mol/m 3 s, m=100 Figure 12.12 Profile of substrate (12a) and product ...

The comparison between both bioreactors was made for different combinations of medium and dodecane fluxes. Two different toxic p ...

results in a higher transfer rate. The transfer rate is also influenced by the distribution coefficient, a higher distribution c ...

Figure 12.13b Distribution coefficient as a function of the maximum substrate conversion for which a three-phase fluidised bed p ...

dodecane hold-up is higher for a higher dodecane flux. Hence, the distribution coefficient has to be higher for the higher dodec ...

oxygen FC40/water 12 Sonsbeek et al., 1992a octene/water 11.4 Meer, 1993 propenoxide toluene/water 3.5 Brink and Tramper, 1985 b ...

0.48, εo= 0.045; X·vmax = 0.01 mol/s, = 100 mol/m3, and m=100. The dimensionless concentrations for a two-phase fluidised bed an ...

Ar area reactor m^2 concentration component in phase j mol/m^3 substrate concentration in medium phase at t=0 mol/m^3 Di diffusi ...

z dimensionless space coordinate in gel bead — Subscripts p product s substrate Superscripts bulk bulk phase int at the interfac ...

Brink, L.E.S. and Tramper, J. (1985) Optimization of Organic Solvent in multiphase biocatalysis. Biotechnol Bioeng., 27, 1258–12 ...

Bioreactors and biotransformations edited by G.W.Moody and P.B.Baker, pp. 231–241. London: Elsevier Science Publ. Vermuë, M.H. a ...

r=0, centre of the gel head r=R, edge of the gel bead The medium phase Substrate t=0, =0, batch operation =0, continuous operati ...

with vwp the slip-velocity between water and gel bead, and vwo the slip-velocity between water and organic phase. The droplet di ...